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Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium

  • Bo Shen*
  • , Gursimran S. Kochhar
  • , Revital Kariv
  • , Xiuli Liu
  • , Udayakumar Navaneethan
  • , David T. Rubin
  • , Raymond K. Cross
  • , Akira Sugita
  • , André D'Hoore
  • , Jason Schairer
  • , Francis A. Farraye
  • , Ravi P. Kiran
  • , Philip Fleshner
  • , Joel Rosh
  • , Samir A. Shah
  • , Shannon Chang
  • , Ellen Scherl
  • , Darrell S. Pardi
  • , David A. Schwartz
  • , Paulo G. Kotze
  • David H. Bruining, Sunanda V. Kane, Jessica Philpott, Bincy Abraham, Jonathan Segal, Rocio Sedano, Maia Kayal, Stuart Bentley-Hibbert, Dino Tarabar, Sandra El-Hachem, Priya Sehgal, James T. McCormick, Joseph A. Picoraro, Mark S. Silverberg, Charles N. Bernstein, William J. Sandborn, Séverine Vermeire
*Corresponding author for this work
  • Columbia University
  • West Penn Allegheny Health System
  • Washington University St. Louis
  • Orlando Regional Medical Center
  • The University of Chicago
  • University of Maryland, Baltimore
  • Yokohama Municipal Citizen's Hospital
  • KU Leuven
  • Henry Ford Health System
  • Mayo Clinic Jacksonville, FL
  • University of California at Los Angeles
  • Goryeb Children's Hospital/Atlantic Health
  • Brown University
  • New York University
  • Cornell University
  • Mayo Clinic Rochester, MN
  • Vanderbilt University
  • Pontifícia Universidade Católica do Paraná
  • Cleveland Clinic Foundation
  • The Hillingdon Hospitals NHS Foundation Trust
  • Western University
  • Icahn School of Medicine at Mount Sinai
  • University Hospital Center Dr Dragiša Mišović
  • University of Toronto
  • University of Manitoba
  • University of California at San Diego

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations

Abstract

Restorative proctocolectomy with ileal pouch–anal anastomosis is an option for most patients with ulcerative colitis or familial adenomatous polyposis who require colectomy. Although the construction of an ileal pouch substantially improves patients' health-related quality of life, the surgery is, directly or indirectly, associated with various structural, inflammatory, and functional adverse sequelae. Furthermore, the surgical procedure does not completely abolish the risk for neoplasia. Patients with ileal pouches often present with extraintestinal, systemic inflammatory conditions. The International Ileal Pouch Consortium was established to create this consensus document on the diagnosis and classification of ileal pouch disorders using available evidence and the panellists' expertise. In a given individual, the condition of the pouch can change over time. Therefore, close monitoring of the activity and progression of the disease is essential to make accurate modifications in the diagnosis and classification in a timely manner.

Original languageEnglish
Pages (from-to)826-849
Number of pages24
JournalThe Lancet Gastroenterology and Hepatology
Volume6
Issue number10
DOIs
StatePublished - Oct 2021

Funding

FundersFunder number
Allegheny General Hospital
Columbia University Ileal Pouch Center
Dan and Jill Wallen Family Fund
Edelman-Jarislowsky Professor of Surgical Sciences
National Institute of Diabetes and Digestive and Kidney DiseasesP30DK042086

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