Diacetyl nadolol: 3-month ocular hypotensive effect in glaucomatous eyes

Efraim Duzman*, Nachum Rosen, Moshe Lazar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In a double-masked, 3-month clinical study the ocular hypotensive effects of diacetyl nadolol (DAN), timolol, and nadolol were compared. When applied topically to the eyes of glaucomatous patients timolol 0·5% was found to be significantly more effective than DAN 2% in controlling IOP at 3 of 10 evaluation periods. Fewer patients, however, developed tolerance to DAN 2% than to timolol 0·5%. DAN 0·5% was also effective in lowering intraocular pressure in 3 of 8 patients tested. Nadolol 2% had no long-term ocular hypotensive effect. Two of 8 patients treated with DAN 2% developed a bilateral periorbital dermatitis and were removed from the study even though their intraocular pressures were well controlled. No other clinically significant local or systemic side effects were observed during the course of the study.

Original languageEnglish
Pages (from-to)668-673
Number of pages6
JournalBritish Journal of Ophthalmology
Issue number10
StatePublished - 1983


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