Diabetes known or newly detected, but not impaired glucose regulation, has a negative influence on 1-year outcome in patients with coronary artery disease: A report from the Euro Heart Survey on diabetes and the heart

Mattie Lenzen, Lars Ryden, John Öhrvik, Malgorzata Bartnik, Klas Malmberg, Wilma Scholte Op Reimer, Maarten L. Simoons, Dieter Andresen, A. John Camm, Wynn Davies, Alessandro Capucci, Samuel Le´vy, Bertil Olsson, Etienne Aliot, Gu¨nter Breithardt, Stuart Cobbe, Jean Yves Le Heuzey, Massimo Santini, Panos Vardas, Malika ManiniClaire Bramley, Vale´rie Laforest, Charles Taylor, Susan Del Gaiso, Kurt Huber, Guy De Backer, Vera Sirakova, Roman Cerbak, Per Thayssen, Seppo Lehto, Jean Jacques Blanc, Franc¸ois Delahaye, Bondo Kobulia, Uwe Zeymer, Dennis Cokkinos, Kristof Karlocai, Ian Graham, Emer Shelley, Shlomo Behar, Aldo Maggioni, Lino Gonc¸alves, Virginija Grabauskiene, Inger Asmussen, Jaap Deckers, Janina Stepinska, Vyacheslav Mareev, Zorana Vasiljevic, Igor Riecansky, Miran F. Kenda, Angeles Alonso, Jose´ Luis Lopez-Sendon, Annika Rosengren, Peter Buser, Tugrul Okay, Oleg Sychov, Kevin Fox, Peter Schofield, David Wood, Alex Battler, Eric Boersma, Kim Fox, Michel Komajda, Keith McGregor, Barbara Mulder, Sylvia Priori, Lars Ryde´n, Alec Vahanian, William Wijns, Sanofi-Aventis, S. V. Grigoryan, I. Apetyan, S. Aroyan, L. Azarapetyan, Anahit Anvari, Michael Gottsauner-Wolf, Stefan Pfaffenberger, Kadriye Aydinkoc, Karim Kalla, Martina Penka, Heinz Drexel, Peter Langer, Luc A. Pierard, Victor Legrand, Dominique Blommaert, E. Schroeder, Isabelle Mancini, P. Geelen, P. Brugada, Marc De Zutter, Christiaan Vrints, Marc Vercammen, Marielle Morissens, Boyanov Borisov, Valentin Asenov Petrov, Maria Marinova, Alexandrova Assen, Rachev Goudev, Yavor Peychev, Vassil Stoyanovsky, Evgeni Stoynev, Stjepan Kranjcevic, Joseph Moutiris, Marios Ioannides, Dominique Evequoz, Jaroslava Spacilova, Miroslav Novak, Martin Eisenberger, Jolana Mullerova, Josef Kautzner, Lucie Riedlbauchova, Jan Petru`, Milos Taborsky, Helle Cappelen, Yasser A. Sharaf, B. S.S. Ibrahim, Khalid Tammam, Aly Saad, Helmy Elghawaby, Hamed Zaky Sherif, Heba Farouk, Arlett Mielke, Markus Engelen, Paulus Kirchhof, Pia Zimmermann, F. Fernandez Aviles, Jeronimo Rubio, F. Malpartida, M. Corona, Luis Tercedor Sanchez, Jose Miguel, Lozano Herrera, Aurelio Quesada, Antonio J.Munoz Garcia, Carlos Sanchez Gonzalez, M. Soledad Alcasena Juango, Jesus Berjon-Reyero, Josep M. Alegret, J. M.Cruz Fernandez, Cesar Carrascosa, Rosillo Antonio Fernandez Romero, Miguel Gonza´lez Lara, Jose´ L.Lopez Sendon, Jose´ Juan Gomez de Diego, Luis Sosa Martin, Maria Irurita, Norbero Herrera Guttierez, Juan Ramon Siles Rubio, Isabel Antorrena, Alicia Bautista Paves, Antonio Salvador, Maria Dolores Orriach, A. Alonso Garcia, Francisco Epelde, Vicente Bertomeu Martinez, Antonio Berruezo Sanchez, Carlos Pinero Galvez, Rafael Fernandez Rivero, Antonio Hernandez Madrid, Gonzalo Baron-Esquivias, Rafael Peinado, Jose´ Antonio Gomez Guindal, Tomas Ripoll Vera, Emilio Luengo Fernandez, Ricardo Gayan, Javier Garcia, Andres Bodegas, Jesus Toril Lopez, Julio Martinez Florez, Cristobal Lozano Cabezas, Eduardo Vazquez Ruiz de Castroviejo, Juan Munoz Bellido, Maria Eugenia Ruiz, Kirsti Savolainen, Markku Nieminen, Lauri Toivonen, Mikko Syvanne, Mervi Pietila, Daniel Galley, Christine Beltra, Alain Gay, J. C. Daubert, Guillaume Lecocq, Christine Poulain, J. G.F.C. Cleland, Rhidian Shelton, A. Choudhury, Gulnara Abuladze, Irina Jashi, Anastasia Tsiavou, G. Giamouzis, N. Dagres, A. Kostopoulou, Domproglou Tsoutsanis, C. Stefanadis, George Latsios, Ioannis Vogiatzis, Alexandros Gotsis, Paraskevi Bozia, Maria Karakiriou, Spyridon Koulouris, John Parissis, George Kostakis, Nikos Kouris, Dimitra Kontogianni, Koutroubas Athanasios, Alexandros Douras, Themistoklis Tsanakis, Mary Marketou, Nikolaos Patsourakos, Laszlo Czopf, Robert Halmosi, Istvan Pre´da, Eva Csoti, Andrea Badics, Boris Strasberg, Nahum A. Freedberg, Amos Katz, Eli Zalzstein, Aviva Grosbard, E. Goldhammer, Menachem Nahir, Menashe Epstein, Ida Vider, David Luria, Lori Mandelzweig, Bruno Aloisi, Alfio Cavallaro, Emanuele Antonielli, Baldassarre Doronzo, Diego Pancaldo, Carlo Mazzola, Liliana Buontempi, Valeria Calvi, Giuseppe Giuffrida, Antonino Figlia, Francesco Ippolito, Gian Paolo Gelmini, N. Gaibazzi, Virgilio Ziacchi, Francesco De Tommasi, Federico Lombardi, Cesare Fiorentini, Paolo Terranova, Pietro Maiolino, Muhamad Albunni, Plinio Pinna-Pintor, Stefano Fumagalli, Guilio Masotti, Lorenzo Boncinelli, Domenico Rossi, Giovanni Maria Santoro, Massimo Fioranelli, Franco Naccarella, Stefano Sdringola Maranga, Giovannina Lepera, Barbara Bresciani, Elena Seragnoli, Mara Cantelli Forti, Valentina Cortina, Giacinto Baciarello, Paolo Cicconetti, Antonio Lax, Federica Vitali, Diran Igidbashian, Luisa Scarpino, Sergio Terrazzino, Luigi Tavazzi, Francesco Cantu, Francesco Pentimalli, Salvatore Novo, Giuseppe Coppola, Gianluca Zingarini, Giuseppe Ambrozio, Paolo Moruzzi, Sergio Callegari, Gabriele Saccomanno, Paolo Russo, Emanuele Carbonieri, Anna Paino, Marco Zanetta, Enzo Barducci, Roberto Cemin, Werner Rauhe, Walter Pitscheider, Marina Meloni, Sergio Mariano Marchi, Marco Di Gennaro, Sergio Calcagno, Paola Squaratti, Francesco Quartili, Patrizia Bertocchi, Mario De Martini, Giuseppe Mantovani, Roman Komorovsky, Alessandro Desideri, Leopoldo Celegon, Luigi Tarantini, Giuseppe Catania, Donata Lucci, Francesca Bianchini, Aras Puodziukynas, Ausra Kavoliuniene, Vilija Barauskiene, Audrius Aidietis, Jurate Barysiene, Vitas Vysniauskas, Irena Zukauskiene, Nijole Kazakeviciene, Ljubica Georgievska-Ismail, Lidija Poposka, Eleonora Vataman, Aurel A. Grosu, Esther de Swart, Chris Jansen, Ritzo Brons, Henriette Tebbe, D. C.A. van Hoogenhuyze, M. J. Veerhoek, Maria Kamps, D. Haan, Nitolanda van Rijn, Annette Bootsma, Leo Baur, Adrie van den, Heidi Fransen, Luc Eurlings, Joan Meeder, M. J. De Boer, Jobst Winter, Herman Broers, Chris Werter, M. Bijl, Saskia Versluis, Malgorzata Milkowska, Beata Wozakowska-Kaplon, Marianna Janion, Lidia Lepska, Grazyna Swiatecka, Piotr Kokowicz, Jacek Cybulski, Aleksandr Gorecki, Marcin Szulc, Jerzy Rekosz, Rafal Manczak, Anna Maria Wnuk-Wojnar, M. Trusz-Gluza, Anna Rybicka-Musialik, Jaroslaw Myszor, Michal Szpajer, Krzysztof Cymerman, Jerzy Sadowski, Maria Sniezek-Maciejewska, Mariola Ciesla-Dul, Izabela Gorkiewicz-Kot, Tomasz Grodzicki, Krzysztof Rewiuk, Leszek Kubik, Jacek Lewit, Joao Manuel Frazao Rodrigues de Sousa, Rafael Ferreira, Antonio Freitas, Joao Carlos Araujo Morais, Rui Pires, M. J.Veloso Gomes, Paula Gago, Rui Alexandre C. Candeias, Luis Nunes, Joao Vitor Miranda Sa, Miguel Ventura, Mario de Oliveira, Luis Brandao Alves, Ioan Bostaca, Codin T. Olariu, G. A. Dan, Anca Dan, Cristian Podoleanu, Attila Frigy, George I.M. Georgescu, Catalina Arsenescu, Cristian Statescu, Radu Sascau, Dan L. Dimitrascu, Raluca Rancea, Yuri V. Shubik, Dmitry Duplyakov, Marina Shalak, Marine Danielyan, Albert Galyavich, Venera Zakirova, Robert Hatala, Gabriela Kaliska, Jan Kmec, Igor Zupan, Jerneja Tasie`, Damijan Vokac, Nils Edvardsson, Dritan Poci, Habib Gamra, Hichem Denguir, Ahmet Sepetoglu, Alev Arat-Ozkan, Mariya Orynchak, Elena Paliy, I. Vakalyuk, David Malidze, Rostyslav Prog, Myckola Ivanovich Yabluchansky, Nataliya Volodimirovna Makienko, Tatjana Potpara, Sofija Knezevic, Miomir Randjelovic

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Although diabetes is known to be a major contributor to cardiovascular diseases, as well as an independent predictor for adverse outcomes in patients with coronary artery disease (CAD), information on the prognosis of patients with CAD and newly diagnosed diabetes or impaired glucose regulation (IGR) is scarce. The objective of this study was to explore 1-year outcome in relation to different glucometabolic states of patients participating in the Euro Heart Survey on diabetes and the heart. Methods and results: In 4676 out of 4961 patients, information on the relation between 1-year outcome and glucometabolic state, which was based on oral glucose tolerance test (OGTT) or fasting glucose plasma, was available. A normal glucose metabolism was identified in 947 patients, IGR (impaired fasting glucose or impaired glucose tolerance) in 1116 patients, and diabetes in 1877 patients of whom 1425 were previously diagnosed and 452 newly diagnosed. In total, 736 patients could not be classified, as no OGTT or fasting plasma glucose was performed. Previously recognized and newly detected diabetes was associated with an increased risk of 1-year mortality when compared with patients with normal glucose regulation [hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.5-3.8 and HR 2.0, 95% CI 1.1-3.6, respectively)]. IGR, however, could not be identified as an independent predictor for 1-year mortality (HR 1.1, 95% CI 0.6-1.9). Conclusion: This study confirmed that patients with CAD and known diabetes are at high risk for mortality and cardiovascular events and demonstrated that patients with newly diagnosed diabetes are at intermediate risk for adverse outcomes. IGR, however, could not be identified as an independent predictor for adverse outcomes during the 1-year follow-up period.

Original languageEnglish
Pages (from-to)2969-2974
Number of pages6
JournalEuropean Heart Journal
Volume27
Issue number24
DOIs
StatePublished - 1 Dec 2006

Keywords

  • Coronary artery disease
  • Diabetes
  • Euro Heart Survey
  • Impaired glucose regulation

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