Diabetes and Cancer

Rachel Dankner

doi:10.1016/B978-0-12-801238-3.65040-7

Diabetes and Cancer

Rachel Dankner^*

^*Corresponding author for this work

School of Public Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The association between diabetes and cancer is complex. Numerous epidemiological studies show temporal associations between diabetes and risks of all-site and of specific cancers, especially of the pancreas, liver, gallbladder, gastrointestinal, and kidney. Hyperglycemia, which defines diabetes, evidently contributes to this risk. In addition, the metabolic milieu that predisposes to diabetes, and that is characterized by obesity, insulin resistance and hyperinsulinemia, altered concentrations of sex hormones, and oxidative stress and inflammation, is conducive to cancer incidence. Genetic and lifestyle factors also provide links between the diseases according to cancer type. No causal relationship of glucose lowering medications on cancer incidence has been demonstrated yet.

Original language	English
Title of host publication	Encyclopedia of Cancer, Third Edition
Subtitle of host publication	Volumes 1-3
Publisher	Elsevier
Pages	V1:459-V1:470
Volume	1
ISBN (Electronic)	9780128124840
ISBN (Print)	9780128124857
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.65040-7
State	Published - 1 Jan 2018

Keywords

Antidiabetic medications
Cancer
Diabetes
Diabetic medications
Glucose lowering medications
Hyperglycemia
Hyperinsulinemia
Inflammation
Insulin resistance
Obesity
Pathophysiology
Risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-801238-3.65040-7

Cite this

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abstract = "The association between diabetes and cancer is complex. Numerous epidemiological studies show temporal associations between diabetes and risks of all-site and of specific cancers, especially of the pancreas, liver, gallbladder, gastrointestinal, and kidney. Hyperglycemia, which defines diabetes, evidently contributes to this risk. In addition, the metabolic milieu that predisposes to diabetes, and that is characterized by obesity, insulin resistance and hyperinsulinemia, altered concentrations of sex hormones, and oxidative stress and inflammation, is conducive to cancer incidence. Genetic and lifestyle factors also provide links between the diseases according to cancer type. No causal relationship of glucose lowering medications on cancer incidence has been demonstrated yet.",

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KW - Diabetes

KW - Diabetic medications

KW - Glucose lowering medications

KW - Hyperglycemia

KW - Hyperinsulinemia

KW - Inflammation

KW - Insulin resistance

KW - Obesity

KW - Pathophysiology

KW - Risk factors

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Diabetes and Cancer

Abstract

Keywords

UN SDGs

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