TY - JOUR
T1 - DHEAS repeated treatment improves cognitive and behavioral deficits after mild traumatic brain injury
AU - Milman, A.
AU - Zohar, O.
AU - Maayan, R.
AU - Weizman, R.
AU - Pick, C. G.
N1 - Funding Information:
Funding for this study was provided by Tel Aviv University internal Grant. Tel Aviv University had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2008/3
Y1 - 2008/3
N2 - Mild traumatic brain injury (mTBI) is characterized by diffused symptoms, which when combined are called "post-concussion syndrome". Dehydroepiandrosterone sulfate (DHEAS) is a neuroactive neurosteroid. Previously, we have reported that closed head mTBI causes long lasting cognitive deficits and depressive-like behavior. In the present study we describe the effects of DHEAS on the behavior of mice that suffered closed head mTBI. Following the induction of mTBI, mice were treated once a week with DHEAS (s.c. 20 mg/kg) and their performance in the passive avoidance test and the forced swimming test (FST) were evaluated 7, 30, 60 and 90 days post-injury. The most important interactions were between injury and injection (passive avoidance; p < 0.001 and FST; p = 0.001), meaning that DHEAS has beneficial effects only when given to injured animals. Our results demonstrate that the long-term cognitive and behavioral effects induced by mTBI may be improved by a repeated weekly treatment with DHEAS.
AB - Mild traumatic brain injury (mTBI) is characterized by diffused symptoms, which when combined are called "post-concussion syndrome". Dehydroepiandrosterone sulfate (DHEAS) is a neuroactive neurosteroid. Previously, we have reported that closed head mTBI causes long lasting cognitive deficits and depressive-like behavior. In the present study we describe the effects of DHEAS on the behavior of mice that suffered closed head mTBI. Following the induction of mTBI, mice were treated once a week with DHEAS (s.c. 20 mg/kg) and their performance in the passive avoidance test and the forced swimming test (FST) were evaluated 7, 30, 60 and 90 days post-injury. The most important interactions were between injury and injection (passive avoidance; p < 0.001 and FST; p = 0.001), meaning that DHEAS has beneficial effects only when given to injured animals. Our results demonstrate that the long-term cognitive and behavioral effects induced by mTBI may be improved by a repeated weekly treatment with DHEAS.
KW - Closed head trauma model
KW - Cognitive deficits
KW - Dehydroepiandrosterone sulfate (DHEAS)
KW - Depressive-like behavior
KW - Mild traumatic brain injury (mTBI)
UR - http://www.scopus.com/inward/record.url?scp=38149025516&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2007.05.007
DO - 10.1016/j.euroneuro.2007.05.007
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C2 - 17669633
AN - SCOPUS:38149025516
SN - 0924-977X
VL - 18
SP - 181
EP - 187
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 3
ER -