Dexamethasone as an adjuvant therapy for anovulatory, normoandrogenic patients during ovulation induction with exogenous gonadotropins

David Bider, Yehezkiel Menashe, Mordechai Goldenberg, Mordechai Dulitzky, Alexander Lifshitz, Jehoshua Dor

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objective of our study was to explore the effect of dexamethasone (DEX), a highly potent, long-acting glucocorticoid, on the treatment outcome of 74 anovulatory women aged 21 to 29 years, with normal gonadotropins, androgen, and prolactin (PRL) serum levels who failed to conceive on antiestrogen therapy. Methods: The patients received human menopausal gonadotropin/human chorionic gonadotropin (hMG/hCG) for ovulation induction. Starting on day 4 of the induced menstruation, hMG was administered in combination with DEX, 0.5 mg at night, or without DEX as an adjuvant treatment. The total amount of gonadotropins used, time required for stimulation, percentage of fertilization, serum estradiol levels, pregnancy rate, cumulative pregnancy rate, and abortions were recorded. Results: There were no differences in either the cumulative pregnancy rate (54.1% in the DEX group and 52.7% in the untreated group) or the abortion rates (21.7% in the DEX group compared to 20.8% in the untreated group). The other parameters investigated also did not differ significantly between the groups. Conclusions: The overall results did not support DEX as a clinically useful adjuvant therapy for anovulatory, normoandrogenic patients.

Original languageEnglish
Pages (from-to)613-616
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Volume13
Issue number8
DOIs
StatePublished - 1996

Keywords

  • anovulation
  • glucocorticoids
  • human chorionic gonadotropin
  • human menopausal gonadotropin

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