Developmental pattern of muscarinic receptors in normal and Down's syndrome fetal brain - An autoradiographic study

Osnat Bar-Peled; Mali Israeli; Herzl Ben-Hur; Iffath Hoskins; Yoram Groner; Anat Biegon

doi:10.1016/0304-3940(91)90558-B

Developmental pattern of muscarinic receptors in normal and Down's syndrome fetal brain - An autoradiographic study

Osnat Bar-Peled^*, Mali Israeli, Herzl Ben-Hur, Iffath Hoskins, Yoram Groner, Anat Biegon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The ontogeny of muscarinic cholinergic receptors in developing human brain was analyzed by in vitro receptor autoradiography with [³H]Quinuclidinyl Benzilate. It was found that muscarinic receptors develop relatively early; the levels at 24 weeks of gestation were comparable or even higher than the values in the adult brain, and that the levels of both M1 and M2 receptors increase with age. M1 receptors were concentrated mainly in forebrain regions while M2 receptors dominated in the thalamus. Scatchard analysis revealed K_d and B_max values which are comparable to the adult values. Three brains of aborted Down's syndrome fetuses were examined in parallel and exhibited comparable levels and similar distribution to normal non-Down fetuses except for a modest increase of receptor levels which was observed in the striatum.

Original language	English
Pages (from-to)	154-158
Number of pages	5
Journal	Neuroscience Letters
Volume	133
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(91)90558-B
State	Published - 9 Dec 1991
Externally published	Yes

Keywords

Down's syndrome
Human fetal brain
Muscarinic receptor

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10.1016/0304-3940(91)90558-B

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title = "Developmental pattern of muscarinic receptors in normal and Down's syndrome fetal brain - An autoradiographic study",

abstract = "The ontogeny of muscarinic cholinergic receptors in developing human brain was analyzed by in vitro receptor autoradiography with [3H]Quinuclidinyl Benzilate. It was found that muscarinic receptors develop relatively early; the levels at 24 weeks of gestation were comparable or even higher than the values in the adult brain, and that the levels of both M1 and M2 receptors increase with age. M1 receptors were concentrated mainly in forebrain regions while M2 receptors dominated in the thalamus. Scatchard analysis revealed Kd and Bmax values which are comparable to the adult values. Three brains of aborted Down's syndrome fetuses were examined in parallel and exhibited comparable levels and similar distribution to normal non-Down fetuses except for a modest increase of receptor levels which was observed in the striatum.",

keywords = "Down's syndrome, Human fetal brain, Muscarinic receptor",

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AU - Bar-Peled, Osnat

AU - Israeli, Mali

AU - Ben-Hur, Herzl

AU - Hoskins, Iffath

AU - Groner, Yoram

AU - Biegon, Anat

PY - 1991/12/9

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N2 - The ontogeny of muscarinic cholinergic receptors in developing human brain was analyzed by in vitro receptor autoradiography with [3H]Quinuclidinyl Benzilate. It was found that muscarinic receptors develop relatively early; the levels at 24 weeks of gestation were comparable or even higher than the values in the adult brain, and that the levels of both M1 and M2 receptors increase with age. M1 receptors were concentrated mainly in forebrain regions while M2 receptors dominated in the thalamus. Scatchard analysis revealed Kd and Bmax values which are comparable to the adult values. Three brains of aborted Down's syndrome fetuses were examined in parallel and exhibited comparable levels and similar distribution to normal non-Down fetuses except for a modest increase of receptor levels which was observed in the striatum.

AB - The ontogeny of muscarinic cholinergic receptors in developing human brain was analyzed by in vitro receptor autoradiography with [3H]Quinuclidinyl Benzilate. It was found that muscarinic receptors develop relatively early; the levels at 24 weeks of gestation were comparable or even higher than the values in the adult brain, and that the levels of both M1 and M2 receptors increase with age. M1 receptors were concentrated mainly in forebrain regions while M2 receptors dominated in the thalamus. Scatchard analysis revealed Kd and Bmax values which are comparable to the adult values. Three brains of aborted Down's syndrome fetuses were examined in parallel and exhibited comparable levels and similar distribution to normal non-Down fetuses except for a modest increase of receptor levels which was observed in the striatum.

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KW - Human fetal brain

KW - Muscarinic receptor

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Developmental pattern of muscarinic receptors in normal and Down's syndrome fetal brain - An autoradiographic study

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