Development of secondary anaplastic oligoastrocytoma after matched unrelated bone marrow transplantation in a child with acute myeloid leukemia

Soumya Panigrahi, Mayukh Das, Dalia Stagler, Shlomi Konstantini, Moshe Gmori, Shimon Slavin, Arnon Nagler

Research output: Contribution to journalArticlepeer-review

Abstract

The growing incidences of secondary malignancies in long-term survivors of childhood leukemia following allogeneic bone marrow transplantation (alloBMT) are increasingly being reported. Among the late complications of conventional myeloablative alloBMT, the occurrence of secondary malignant solid tumors is of major concern. Secondary malignant and benign brain tumors such as astrocytoma, meningioma and glioblastoma have been described in long-term survivors of conventional myeloablative alloBMT. Here we report a case of secondary anaplastic oligoastrocytoma that developed 7 years after matched unrelated alloBMT for relapsing childhood acute myeloid leukemia (AML) with CNS involvement. Although isolated CNS relapse of primary leukemia following alloBMT is not uncommon, it is important to identify and define potential risk factors that may lead to the development of secondary brain tumors in children who received high-dose chemotherapy and irradiation prior to alloBMT presenting with progressive neurological symptoms and to differentiate them from leukemia relapse with CNS involvement.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalActa Haematologica
Volume109
Issue number4
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Bone marrow transplantation, allogeneic
  • CNS insult
  • Oligoastrocytoma

Fingerprint

Dive into the research topics of 'Development of secondary anaplastic oligoastrocytoma after matched unrelated bone marrow transplantation in a child with acute myeloid leukemia'. Together they form a unique fingerprint.

Cite this