Development and bench testing of a multi-spectral imaging technology built on a smartphone platform

Frank J. Bolton, Reuven Weiser, Alex J. Kass, Donny Rose, Amit Safir, David Levitz*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Cervical cancer screening presents a great challenge for clinicians across the developing world. In many countries, cervical cancer screening is done by visualization with the naked eye. Simple brightfield white light imaging with photo documentation has been shown to make a significant impact on cervical cancer care. Adoption of smartphone based cervical imaging devices is increasing across Africa. However, advanced imaging technologies such as multispectral imaging systems, are seldom deployed in low resource settings, where they are needed most. To address this challenge, the optical system of a smartphone-based mobile colposcopy imaging system was refined, integrating components required for low cost, portable multi-spectral imaging of the cervix. This paper describes the refinement of the mobile colposcope to enable it to acquire images of the cervix at multiple illumination wavelengths, including modeling and laboratory testing. Wavelengths were selected to enable quantifying the main absorbers in tissue (oxyand deoxy-hemoglobin, and water), as well as scattering parameters that describe the size distribution of scatterers. The necessary hardware and software modifications are reviewed. Initial testing suggests the multi-spectral mobile device holds promise for use in low-resource settings.

Original languageEnglish
Title of host publicationOptics and Biophotonics in Low-Resource Settings II
EditorsDavid Erickson, David Levitz, Aydogan Ozcan
ISBN (Electronic)9781628419337
StatePublished - 2016
EventOptics and Biophotonics in Low-Resource Settings II - San Francisco, United States
Duration: 13 Feb 201614 Feb 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptics and Biophotonics in Low-Resource Settings II
Country/TerritoryUnited States
CitySan Francisco


  • 3D printing
  • Low resource settings
  • colposcopy
  • imaging
  • mobile
  • multispectral
  • translational research


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