Deubiquitylating enzymes in neuronal health and disease

Fatima Amer-Sarsour, Alina Kordonsky, Yevgeny Berdichevsky, Gali Prag, Avraham Ashkenazi

Research output: Contribution to journalReview articlepeer-review

Abstract

Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Figure not available: see fulltext.]

Original languageEnglish
Article number120
JournalCell Death and Disease
Volume12
Issue number1
DOIs
StatePublished - Jan 2021

Fingerprint

Dive into the research topics of 'Deubiquitylating enzymes in neuronal health and disease'. Together they form a unique fingerprint.

Cite this