Deubiquitylating enzymes in neuronal health and disease

Fatima Amer-Sarsour, Alina Kordonsky, Yevgeny Berdichevsky, Gali Prag*, Avraham Ashkenazi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Figure not available: see fulltext.]

Original languageEnglish
Article number120
JournalCell Death and Disease
Issue number1
StatePublished - Jan 2021


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