TY - JOUR
T1 - Deubiquitylating enzymes in neuronal health and disease
AU - Amer-Sarsour, Fatima
AU - Kordonsky, Alina
AU - Berdichevsky, Yevgeny
AU - Prag, Gali
AU - Ashkenazi, Avraham
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/1
Y1 - 2021/1
N2 - Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Figure not available: see fulltext.]
AB - Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Figure not available: see fulltext.]
UR - http://www.scopus.com/inward/record.url?scp=85099986774&partnerID=8YFLogxK
U2 - 10.1038/s41419-020-03361-5
DO - 10.1038/s41419-020-03361-5
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C2 - 33483467
AN - SCOPUS:85099986774
SN - 2041-4889
VL - 12
JO - Cell Death and Disease
JF - Cell Death and Disease
IS - 1
M1 - 120
ER -
