Determining the source of fetal adiponectin

Shali Mazaki-Tovi, Hannah Kanety, Clara Pariente, Rina Hemi, Yael Efraty, Eyal Schiff, Ann Shoham, Eyal Sivan

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To determine whether maternal, placental or fetal compartment contributes to the high levels of cord blood adiponectin. STUDY DESIGN: Serum adiponectin levels were compared from 62 newborns and their mothers as well as 32 newborns at delivery and 4 days postpartum. In addition, human placental tissues were tested for the presence of adiponectin mRNA by reverse transcriptase polymerase chain reaction. RESULTS: Cord blood serum adiponectin levels were significantly higher and did not correlate with maternal adiponectin levels (32.5 ± 7.5 vs. 11.0 ± 3.6 μg/mL, p < 0.001). Cord blood and day 4 serum adiponectin did not differ significantly (32.6 ± 7.6 vs. 29.5 ± 8.4 μg/mL, p < 0.3). In addition, adiponectin mRNA was not expressed in the placenta. CONCLUSION: These findings preclude the possibility of a placental or maternal origin of cord adiponectin. Thus, the high cord adiponectin levels may be attributed to fetal tissues.

Original languageEnglish
Pages (from-to)774-778
Number of pages5
JournalThe Journal of reproductive medicine
Volume52
Issue number9
StatePublished - Sep 2007

Keywords

  • Adiponectin
  • Fetus
  • Umbilical cord

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