OBJECTIVE: To determine whether maternal, placental or fetal compartment contributes to the high levels of cord blood adiponectin. STUDY DESIGN: Serum adiponectin levels were compared from 62 newborns and their mothers as well as 32 newborns at delivery and 4 days postpartum. In addition, human placental tissues were tested for the presence of adiponectin mRNA by reverse transcriptase polymerase chain reaction. RESULTS: Cord blood serum adiponectin levels were significantly higher and did not correlate with maternal adiponectin levels (32.5 ± 7.5 vs. 11.0 ± 3.6 μg/mL, p < 0.001). Cord blood and day 4 serum adiponectin did not differ significantly (32.6 ± 7.6 vs. 29.5 ± 8.4 μg/mL, p < 0.3). In addition, adiponectin mRNA was not expressed in the placenta. CONCLUSION: These findings preclude the possibility of a placental or maternal origin of cord adiponectin. Thus, the high cord adiponectin levels may be attributed to fetal tissues.
|Number of pages||5|
|Journal||The Journal of reproductive medicine|
|State||Published - Sep 2007|
- Umbilical cord