Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing

Eli Somekh, Zahava Smetana, Amir Tanay, Ilan Dalal, Ilan Babai, Ella Mendelson

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the usefulness of skin test prepared by inactivation of vaccinia vaccine in predicting immunity to vaccinia. Skin test was injected to 77 healthy adults. Twenty had a recent smallpox vaccination (group 1). Thirty-seven were long term vacinees (group 2), while 20 subjects had never been vaccinated for smallpox (group 3). Mean size of induration was 7.9, 5.3 and 0.4 mm for subjects from groups 1, 2 and 3, respectively (P < 0.03 for difference between groups). Induration ≥5 mm correlated with neutralizing antibody titer >1:32 (r = 0.73, P < 0.0001). The skin test is a potentially useful tool for the assessment of immunity to vaccinia.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalVaccine
Volume23
Issue number3
DOIs
StatePublished - 2 Dec 2004
Externally publishedYes

Keywords

  • Immunity
  • Skin test
  • Vaccinia

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