Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing

Eli Somekh; Zahava Smetana; Amir Tanay; Ilan Dalal; Ilan Babai; Ella Mendelson

doi:10.1016/j.vaccine.2004.06.005

Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing

Eli Somekh, Zahava Smetana, Amir Tanay, Ilan Dalal, Ilan Babai, Ella Mendelson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We evaluated the usefulness of skin test prepared by inactivation of vaccinia vaccine in predicting immunity to vaccinia. Skin test was injected to 77 healthy adults. Twenty had a recent smallpox vaccination (group 1). Thirty-seven were long term vacinees (group 2), while 20 subjects had never been vaccinated for smallpox (group 3). Mean size of induration was 7.9, 5.3 and 0.4 mm for subjects from groups 1, 2 and 3, respectively (P < 0.03 for difference between groups). Induration ≥5 mm correlated with neutralizing antibody titer >1:32 (r = 0.73, P < 0.0001). The skin test is a potentially useful tool for the assessment of immunity to vaccinia.

Original language	English
Pages (from-to)	321-324
Number of pages	4
Journal	Vaccine
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.vaccine.2004.06.005
State	Published - 2 Dec 2004
Externally published	Yes

Keywords

Immunity
Skin test
Vaccinia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2004.06.005

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title = "Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing",

abstract = "We evaluated the usefulness of skin test prepared by inactivation of vaccinia vaccine in predicting immunity to vaccinia. Skin test was injected to 77 healthy adults. Twenty had a recent smallpox vaccination (group 1). Thirty-seven were long term vacinees (group 2), while 20 subjects had never been vaccinated for smallpox (group 3). Mean size of induration was 7.9, 5.3 and 0.4 mm for subjects from groups 1, 2 and 3, respectively (P < 0.03 for difference between groups). Induration ≥5 mm correlated with neutralizing antibody titer >1:32 (r = 0.73, P < 0.0001). The skin test is a potentially useful tool for the assessment of immunity to vaccinia.",

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T1 - Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing

AU - Somekh, Eli

AU - Smetana, Zahava

AU - Tanay, Amir

AU - Dalal, Ilan

AU - Babai, Ilan

AU - Mendelson, Ella

PY - 2004/12/2

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AB - We evaluated the usefulness of skin test prepared by inactivation of vaccinia vaccine in predicting immunity to vaccinia. Skin test was injected to 77 healthy adults. Twenty had a recent smallpox vaccination (group 1). Thirty-seven were long term vacinees (group 2), while 20 subjects had never been vaccinated for smallpox (group 3). Mean size of induration was 7.9, 5.3 and 0.4 mm for subjects from groups 1, 2 and 3, respectively (P < 0.03 for difference between groups). Induration ≥5 mm correlated with neutralizing antibody titer >1:32 (r = 0.73, P < 0.0001). The skin test is a potentially useful tool for the assessment of immunity to vaccinia.

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KW - Vaccinia

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Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing

Abstract

Keywords

UN SDGs

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