Determination of autoantibodies in patients with familial Mediterranean fever and their first degree relatives

M. Swissa; V. Schul; S. Korish; A. Livneh; M. Pras; Y. Shoenfeld

Determination of autoantibodies in patients with familial Mediterranean fever and their first degree relatives

M. Swissa, V. Schul, S. Korish, A. Livneh, M. Pras, Y. Shoenfeld^*

^*Corresponding author for this work

Sheba Medical Center at Tel Hashomer

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Sera samples of 168 patients with familial Mediterranean fever (FMF) and their 184 first degree relatives were analyzed for the presence of autoantibodies to ssDNA, dsDNA, poly (I), poly (G), cardiolipin, histones, RNP and Ro(SSA), using an enzyme linked immunosorbent assay (ELISA). A similar analysis was employed on culture fluids of Epstein-Barr virus (EBV) transformed B lymphocytes derived from patients with FMF and healthy controls. No increased incidence of these antibodies was observed among patients with FMF and their relatives compared to healthy controls. It is possible that autoimmune features observed in FMF are the result of nonspecific changes occurring in inflammation and not due to autoimmune mechanisms.

Original language	English
Pages (from-to)	606-608
Number of pages	3
Journal	Journal of Rheumatology
Volume	18
Issue number	4
State	Published - 1991
Externally published	Yes

Keywords

Autoantibodies
Autoimmunity
Familial Mediterranean fever

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title = "Determination of autoantibodies in patients with familial Mediterranean fever and their first degree relatives",

abstract = "Sera samples of 168 patients with familial Mediterranean fever (FMF) and their 184 first degree relatives were analyzed for the presence of autoantibodies to ssDNA, dsDNA, poly (I), poly (G), cardiolipin, histones, RNP and Ro(SSA), using an enzyme linked immunosorbent assay (ELISA). A similar analysis was employed on culture fluids of Epstein-Barr virus (EBV) transformed B lymphocytes derived from patients with FMF and healthy controls. No increased incidence of these antibodies was observed among patients with FMF and their relatives compared to healthy controls. It is possible that autoimmune features observed in FMF are the result of nonspecific changes occurring in inflammation and not due to autoimmune mechanisms.",

keywords = "Autoantibodies, Autoimmunity, Familial Mediterranean fever",

author = "M. Swissa and V. Schul and S. Korish and A. Livneh and M. Pras and Y. Shoenfeld",

year = "1991",

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T1 - Determination of autoantibodies in patients with familial Mediterranean fever and their first degree relatives

AU - Swissa, M.

AU - Schul, V.

AU - Korish, S.

AU - Livneh, A.

AU - Pras, M.

AU - Shoenfeld, Y.

PY - 1991

Y1 - 1991

N2 - Sera samples of 168 patients with familial Mediterranean fever (FMF) and their 184 first degree relatives were analyzed for the presence of autoantibodies to ssDNA, dsDNA, poly (I), poly (G), cardiolipin, histones, RNP and Ro(SSA), using an enzyme linked immunosorbent assay (ELISA). A similar analysis was employed on culture fluids of Epstein-Barr virus (EBV) transformed B lymphocytes derived from patients with FMF and healthy controls. No increased incidence of these antibodies was observed among patients with FMF and their relatives compared to healthy controls. It is possible that autoimmune features observed in FMF are the result of nonspecific changes occurring in inflammation and not due to autoimmune mechanisms.

AB - Sera samples of 168 patients with familial Mediterranean fever (FMF) and their 184 first degree relatives were analyzed for the presence of autoantibodies to ssDNA, dsDNA, poly (I), poly (G), cardiolipin, histones, RNP and Ro(SSA), using an enzyme linked immunosorbent assay (ELISA). A similar analysis was employed on culture fluids of Epstein-Barr virus (EBV) transformed B lymphocytes derived from patients with FMF and healthy controls. No increased incidence of these antibodies was observed among patients with FMF and their relatives compared to healthy controls. It is possible that autoimmune features observed in FMF are the result of nonspecific changes occurring in inflammation and not due to autoimmune mechanisms.

KW - Autoantibodies

KW - Autoimmunity

KW - Familial Mediterranean fever

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JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 4

ER -

Determination of autoantibodies in patients with familial Mediterranean fever and their first degree relatives

Abstract

Keywords

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