Determination of autoantibodies in patients with familial Mediterranean fever and their first degree relatives

M. Swissa, V. Schul, S. Korish, A. Livneh, M. Pras, Y. Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Sera samples of 168 patients with familial Mediterranean fever (FMF) and their 184 first degree relatives were analyzed for the presence of autoantibodies to ssDNA, dsDNA, poly (I), poly (G), cardiolipin, histones, RNP and Ro(SSA), using an enzyme linked immunosorbent assay (ELISA). A similar analysis was employed on culture fluids of Epstein-Barr virus (EBV) transformed B lymphocytes derived from patients with FMF and healthy controls. No increased incidence of these antibodies was observed among patients with FMF and their relatives compared to healthy controls. It is possible that autoimmune features observed in FMF are the result of nonspecific changes occurring in inflammation and not due to autoimmune mechanisms.

Original languageEnglish
Pages (from-to)606-608
Number of pages3
JournalJournal of Rheumatology
Volume18
Issue number4
StatePublished - 1991
Externally publishedYes

Keywords

  • Autoantibodies
  • Autoimmunity
  • Familial Mediterranean fever

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