@article{46ad865a7df04e5cb006e076cb77f4ae,
title = "Detergent solubilization of lipid bilayers: A balance of driving forces",
abstract = "Although detergents are routine tools in biomembrane research, their use remains empirical. We propose that solubilization is the result of a balance between two parameters: (i) the energy associated with bending of phospholipid monolayers into a curved micellar surface, and (ii) the energy associated with filling the void in the center of the resultant mixed micelle. In this review, we show that reliable data on the phase boundaries, and their dependence on various conditions, are consistent with this hypothesis, even if the data might have been interpreted differently. Although most of the experimental data discussed here were obtained with the non-ionic detergent Triton X-100, the conclusions should be applicable to a wide variety of detergents.",
keywords = "Bilayers, Cholesterol, Detergent(s), Liposomes, Mixed micelles, Phospholipids, Solubilization, Spontaneous curvature",
author = "Dov Lichtenberg and Hasna Ahyayauch and Alicia Alonso and Go{\~n}i, {F{\'e}lix M.}",
note = "Funding Information: This work was supported in part by grants BFU 2007-62062 (F.M.G.) and BFU 2011-28566 (A.A.) from the Spanish Ministry of Economy. We also wish to thank the Lady Davis Fund and Bizkaia-Xede for financial support and Prof. Misha Kozlov for helpful discussions.",
year = "2013",
month = feb,
doi = "10.1016/j.tibs.2012.11.005",
language = "אנגלית",
volume = "38",
pages = "85--93",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier Ltd.",
number = "2",
}