Detergent-resistant membranes should not be identified with membrane rafts

Dov Lichtenberg, Félix M. Goñi*, Heiko Heerklotz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Three originally distinct concepts - lipid rafts, detergent-resistant membranes (DRMs) and liquid-ordered (lo) lipid phases - are often confused in current literature; many researchers have assumed that all three names refer to the same chemico-biological entity. In fact, theoretical and experimental findings provide strong evidence against identifying DRMs with rafts and lo domains. Because much of what we think we know about lipid rafts is based on their unjustified identification as DRMs, functional domains in biological membranes might differ markedly from the generally accepted picture.

Original languageEnglish
Pages (from-to)430-436
Number of pages7
JournalTrends in Biochemical Sciences
Issue number8
StatePublished - Aug 2005


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