TY - JOUR
T1 - Detergent-resistant membranes should not be identified with membrane rafts
AU - Lichtenberg, Dov
AU - Goñi, Félix M.
AU - Heerklotz, Heiko
N1 - Funding Information:
Financial support is acknowledged from the Swiss National Science foundation (grant #31–67216.01) to H.H., the Spanish Ministerio de Educación y Ciencia (grant #BFU 2004–02955) and the University of the Basque Country (grant #13552/2001) to F.M.G., and the Israel Science Foundation to D.L. We are grateful to M. Kozlov and A. Alonso for critically reading the article, and to E. Schnitzer for many helpful discussions and for technical assistance.
PY - 2005/8
Y1 - 2005/8
N2 - Three originally distinct concepts - lipid rafts, detergent-resistant membranes (DRMs) and liquid-ordered (lo) lipid phases - are often confused in current literature; many researchers have assumed that all three names refer to the same chemico-biological entity. In fact, theoretical and experimental findings provide strong evidence against identifying DRMs with rafts and lo domains. Because much of what we think we know about lipid rafts is based on their unjustified identification as DRMs, functional domains in biological membranes might differ markedly from the generally accepted picture.
AB - Three originally distinct concepts - lipid rafts, detergent-resistant membranes (DRMs) and liquid-ordered (lo) lipid phases - are often confused in current literature; many researchers have assumed that all three names refer to the same chemico-biological entity. In fact, theoretical and experimental findings provide strong evidence against identifying DRMs with rafts and lo domains. Because much of what we think we know about lipid rafts is based on their unjustified identification as DRMs, functional domains in biological membranes might differ markedly from the generally accepted picture.
UR - http://www.scopus.com/inward/record.url?scp=22744437388&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2005.06.004
DO - 10.1016/j.tibs.2005.06.004
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AN - SCOPUS:22744437388
SN - 0968-0004
VL - 30
SP - 430
EP - 436
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 8
ER -