@article{1a636c87298346588092e089009d0a80,
title = "Detection of microscopic anisotropy in gray matter and in a novel tissue phantom using double Pulsed Gradient Spin Echo MR",
abstract = "A double Pulsed Gradient Spin Echo (d-PGSE) MR experiment was used to measure and assess the degree of local diffusion anisotropy in brain gray matter, and in a novel {"}gray matter{"} phantom that consists of randomly oriented tubes filled with water. In both samples, isotropic diffusion was observed at a macroscopic scale while anisotropic diffusion was observed at a microscopic scale, however, the nature of the resulting echo attenuation profiles were qualitatively different. Gray matter, which contains multiple cell types and fibers, exhibits a more complicated echo attenuation profile than the phantom. Since microscopic anisotropy was observed in both samples in the low q regime comparable to that achievable in clinical scanner, it may offer a new potential contrast mechanism for characterizing gray matter microstructure in medical and biological applications.",
keywords = "Anisotropic, Brain, Diffusion, Gray matter, Isotropic, MR, Macroscopic, Microscopic, Phantom, Pulsed gradient, Restriction, Spin echo",
author = "Komlosh, {M. E.} and F. Horkay and Freidlin, {R. Z.} and U. Nevo and Y. Assaf and Basser, {P. J.}",
note = "Funding Information: The authors thank Dr. H.D. Morris and Dr. M.J. Lizak for helping with all technical aspects of the experiments and Dr. R.E. Rycyna from Bruker Biospin for writing the NMR pulse sequences. We also thank the people who were involved in providing biological specimens: Mr. R.R. Clevenger, Mr. T.J. Hunt, Ms. G.J. Zywicke, Mr. A.D. Zetts, Mrs. K. Keeran, Mr. S.M. Kozlov and Mr. K.R. Jeffries, from LAMS, NHLBI, for supplying fixed pig spinal cord tissue, and Dr. M.A. Eckhaus and Dr. M.F. Starost, from the Division of Veterinary Resources, Office of Research Services, for supplying sections of fixed Rhesus monkey brain. M.E.K. thanks Prof. P.T. Callaghan for helpful comments on this work. This research was supported by the Intramural Program of the National Institute of Child Health and Human Development (NICHD), National Institutes of Health. ",
year = "2007",
month = nov,
doi = "10.1016/j.jmr.2007.07.003",
language = "אנגלית",
volume = "189",
pages = "38--45",
journal = "Journal of Magnetic Resonance",
issn = "1090-7807",
publisher = "Academic Press Inc.",
number = "1",
}