Abstract
Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.
Original language | English |
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Pages (from-to) | 250-258 |
Number of pages | 9 |
Journal | Clinical Immunology and Immunopathology |
Volume | 42 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1987 |
Externally published | Yes |