TY - JOUR
T1 - Detection of anti-histone activity in sera of patients with monoclonal gammopathies
AU - Shoenfeld, Y.
AU - El-Roeiy, A.
AU - Ben-Yehuda, O.
AU - Pick, A. I.
N1 - Funding Information:
’ This work was supported by Research Foundation.
PY - 1987/2
Y1 - 1987/2
N2 - Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.
AB - Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.
UR - http://www.scopus.com/inward/record.url?scp=0023133792&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(87)90012-2
DO - 10.1016/0090-1229(87)90012-2
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0023133792
SN - 0090-1229
VL - 42
SP - 250
EP - 258
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -