Detection of anti-histone activity in sera of patients with monoclonal gammopathies

Y. Shoenfeld*, A. El-Roeiy, O. Ben-Yehuda, A. I. Pick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.

Original languageEnglish
Pages (from-to)250-258
Number of pages9
JournalClinical Immunology and Immunopathology
Volume42
Issue number2
DOIs
StatePublished - Feb 1987
Externally publishedYes

Funding

FundersFunder number
ASCRS Research Foundation

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