Detection of anti-histone activity in sera of patients with monoclonal gammopathies

Y. Shoenfeld, A. El-Roeiy, O. Ben-Yehuda, A. I. Pick

Research output: Contribution to journalArticlepeer-review


Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.

Original languageEnglish
Pages (from-to)250-258
Number of pages9
JournalClinical Immunology and Immunopathology
Issue number2
StatePublished - Feb 1987
Externally publishedYes


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