Detection of anti-histone activity in sera of patients with monoclonal gammopathies

Y. Shoenfeld; A. El-Roeiy; O. Ben-Yehuda; A. I. Pick

doi:10.1016/0090-1229(87)90012-2

Detection of anti-histone activity in sera of patients with monoclonal gammopathies

Y. Shoenfeld, A. El-Roeiy, O. Ben-Yehuda, A. I. Pick

Research output: Contribution to journal › Article › peer-review

Abstract

Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.

Original language	English
Pages (from-to)	250-258
Number of pages	9
Journal	Clinical Immunology and Immunopathology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(87)90012-2
State	Published - Feb 1987
Externally published	Yes

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10.1016/0090-1229(87)90012-2

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title = "Detection of anti-histone activity in sera of patients with monoclonal gammopathies",

abstract = "Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenstr{\"o}m's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.",

author = "Y. Shoenfeld and A. El-Roeiy and O. Ben-Yehuda and Pick, {A. I.}",

note = "Funding Information: {\textquoteright} This work was supported by Research Foundation.",

year = "1987",

month = feb,

doi = "10.1016/0090-1229(87)90012-2",

language = "אנגלית",

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T1 - Detection of anti-histone activity in sera of patients with monoclonal gammopathies

AU - Shoenfeld, Y.

AU - El-Roeiy, A.

AU - Ben-Yehuda, O.

AU - Pick, A. I.

N1 - Funding Information: ’ This work was supported by Research Foundation.

PY - 1987/2

Y1 - 1987/2

N2 - Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.

AB - Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.

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JO - Clinical Immunology

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Detection of anti-histone activity in sera of patients with monoclonal gammopathies

Abstract

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