In an open prospective study we investigated the efficacy of intranasal administration of 1-desamino-8-D-arginine vasopressin (DDAVP) in enuretic adults during military service. Twelve male enuretic soldiers aged 18-19 years (18.9 ± 0.5 years), with a history of resistance to tricyclic antidepressant treatment and to behavioural therapy, were included in the study. Patients were treated with 20-40 mg (bedtime dose) DDAVP. A significant decrease in the frequency of enuresis was demonstrated (3.4 ± 4.3 versus baseline of 8.2 ± 3.3 days, p = 0.01). Four patients achieved complete dryness and four patients achieved partial response. It seems that intranasal DDAVP can be an effective and safe treatment in young adult sleep-related enuresis.
|Number of pages||3|
|State||Published - Sep 1997|
- 1-desamino-8-D-arginine vasopressin (DDAVP desmopressin)
- Sleep-related enuresis
- Tricyclic antidepressants