TY - JOUR
T1 - Desensitization to gonadotropic hormones
T2 - A model system for the regulation of a G-protein-coupled receptor with 7-transmembrane spanning regions
AU - Hirsh, Liron
AU - Ben-Ami, Ido
AU - Freimann, Sarit
AU - Dantes, Ada
AU - Tajima, Kimihisa
AU - Kotsuji, Fumikazu
AU - Amsterdam, Abraham
N1 - Funding Information:
We thank Dr. F. Kohen for critical reading of the manuscript. This study was supported by grants from the La Fondation Raphael and Regina Levy and for Women Health at the Weizmann Institute of Science, Rehovot, Israel. A. Amsterdam is the incumbent of the Joyce and Ben B. Eisenberg professorial chair in molecular Endocrinology and Cancer Research at the Weizmann Institute of Science.
PY - 2004/12/31
Y1 - 2004/12/31
N2 - Gonadotropic hormone, luteinizing hormone, and follicle-stimulating hormone exert their effect via activation of G-coupled receptors, which activate the hormone sensitive adenylyl cyclase, protein kinase A, and cyclic AMP responsive elements. This activation leads to specific de novo synthesis of steroidogenic factors and steroidogenic enzymes. In normal cells and following activation of this signaling pathway, desensitization period will be followed. This down-regulation, which was studied in detail for the last three decays, was found to take place at various steps of these signal transduction pathways as well as at different kinetics. A common and diverse feature of the mechanism of desensitization in other G-coupled-7-transmembrane receptor system is also discussed.
AB - Gonadotropic hormone, luteinizing hormone, and follicle-stimulating hormone exert their effect via activation of G-coupled receptors, which activate the hormone sensitive adenylyl cyclase, protein kinase A, and cyclic AMP responsive elements. This activation leads to specific de novo synthesis of steroidogenic factors and steroidogenic enzymes. In normal cells and following activation of this signaling pathway, desensitization period will be followed. This down-regulation, which was studied in detail for the last three decays, was found to take place at various steps of these signal transduction pathways as well as at different kinetics. A common and diverse feature of the mechanism of desensitization in other G-coupled-7-transmembrane receptor system is also discussed.
KW - Desensitization
KW - G-coupled receptor
KW - Gonadotropin
KW - Steroidogenesis
UR - http://www.scopus.com/inward/record.url?scp=9644287836&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2004.10.168
DO - 10.1016/j.bbrc.2004.10.168
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AN - SCOPUS:9644287836
SN - 0006-291X
VL - 326
SP - 1
EP - 6
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -