Desalinated seawater supply and all-cause mortality in hospitalized acute myocardial infarction patients from the Acute Coronary Syndrome Israeli Survey 2002–2013

Meital Shlezinger, Yona Amitai, Ilan Goldenberg, Michael Shechter

Research output: Contribution to journalArticlepeer-review

Abstract

Background Consuming desalinated seawater (DSW) as drinking water (DW) may reduce magnesium in water intake causing hypomagnesemia and adverse cardiovascular effects. Methods We evaluated 30-day and 1-year all-cause mortality of acute myocardial infarction (AMI) patients enrolled in the biannual Acute Coronary Syndrome Israeli Survey (ACSIS) during 2002–2013. Patients (n = 4678) were divided into 2 groups: those living in regions supplied by DSW (n = 1600, 34.2%) and non-DSW (n = 3078, 65.8%). Data were compared between an early period [2002–2006 surveys (n = 2531) — before desalination] and a late period [2008–2013 surveys (n = 2147) — during desalination]. Results Thirty-day all-cause-mortality was significantly higher in the late period in patients from the DSW regions compared with those from the non-DSW regions (HR = 2.35 CI 95% 1.33–4.15, P < 0.001) while in the early period there was no significant difference (HR = 1.37 CI 95% 0.9–2, P = 0.14). Likewise, there was a significantly higher 1-year all-cause mortality in the late period in patients from DSW regions compared with those from the non-DSW regions (HR = 1.87 CI 95% 1.32–2.63, P < 0.0001), while in the early period there was no significant difference (HR = 1.17 CI 95% 0.9–1.5, P = 0.22). Admission serum magnesium level (M ± SD) in the DSW regions (n = 130) was 1.94 ± 0.24 mg/dL compared with 2.08 ± 0.27 mg/dL in 81 patients in the non-DSW (P < 0.0001). Conclusions Higher 30-day and 1-year all-cause mortality in AMI patients, found in the DSW regions may be attributed to reduced magnesium intake secondary to DSW consumption.

Original languageEnglish
Pages (from-to)544-550
Number of pages7
JournalInternational Journal of Cardiology
Volume220
DOIs
StatePublished - 1 Oct 2016

Keywords

  • Acute myocardial infarction
  • Cardiovascular
  • Desalinated sea water
  • Drinking water
  • Magnesium
  • Major adverse cardiovascular events

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