TY - JOUR
T1 - Dermoscopic spectrum of mycosis fungoides
T2 - a retrospective observational study by the International Dermoscopy Society
AU - Errichetti, E.
AU - Apalla, Z.
AU - Geller, S.
AU - Sławińska, M.
AU - Kyrgidis, A.
AU - Kaminska-Winciorek, G.
AU - Jurakic Toncic, R.
AU - Bobos, M.
AU - Rados, J.
AU - Ledic Drvar, D.
AU - Ceovic, R.
AU - Akay, B. N.
AU - Piccolo, V.
AU - Myskowski, P.
AU - Vitiello, P.
AU - Russo, T.
AU - Argenziano, G.
AU - Sokołowska-Wojdyło, M.
AU - Sobjanek, M.
AU - Stojkovic-Filipovic, J.
AU - Longo, C.
AU - Pellacani, G.
AU - Stinco, G.
AU - Lallas, A.
N1 - Publisher Copyright:
© 2022 European Academy of Dermatology and Venereology.
PY - 2022/7
Y1 - 2022/7
N2 - Background: The dermoscopic features of classic patch stage mycosis fungoides (MF) have been described, but data on plaque and tumoral stage as well as rarer MF subtypes is limited. Objective: To evaluate dermoscopic morphology and dermoscopic-pathological correlations of classic MF stages and investigate dermoscopic features of MF variants. Methods: Patients with histopathologically confirmed lesions of classic MF (patch, plaque and tumoral stage) or folliculotropic, erythrodermic and poikilodermatous MF were included. Standardized evaluation of dermoscopic pictures of the included MF variants and comparative analysis and dermoscopic-pathological correlation assessment of different stages of classic MF were performed. Results: A total of 118 instances were included (75 classic MF, 26 folliculotropic MF, 9 erythrodermic MF and 8 poikilodermatous MF). Linear/linear-curved vessels and white scales in the skin furrows were significantly associated with patch-stage MF, while clustered dotted vessels were related to plaque-stage MF and peripheral linear vessels with branches, ulceration and red globules separated by white lines to tumour-stage MF. Moreover, patchy white scales were significantly more common in patches and plaques compared to tumours, whereas focal bright white structureless areas were related to plaque and tumoral stage. Vessels histopathologically corresponded to dilated vascular structures in the dermis, orange structureless areas to either dermal hemosiderin (patch/plaque stage) or dense cellular infiltration (tumours), bright white lines/structureless areas to dermal fibrosis and ulceration to loss of epidermis. The main dermoscopic findings of folliculotropic MF were lack of hairs, dilated follicles and follicular plugs, while erythrodermic MF was mainly characterized by linear/dotted vessels, patchy white scales and focal orange structureless areas and poikilodermatous MF by focal white and brown structureless areas, white patchy scales and brown reticular lines. Conclusion: Dermoscopy may allow a more precise characterization of classic MF and reveal clues suggestive of the main MF variants.
AB - Background: The dermoscopic features of classic patch stage mycosis fungoides (MF) have been described, but data on plaque and tumoral stage as well as rarer MF subtypes is limited. Objective: To evaluate dermoscopic morphology and dermoscopic-pathological correlations of classic MF stages and investigate dermoscopic features of MF variants. Methods: Patients with histopathologically confirmed lesions of classic MF (patch, plaque and tumoral stage) or folliculotropic, erythrodermic and poikilodermatous MF were included. Standardized evaluation of dermoscopic pictures of the included MF variants and comparative analysis and dermoscopic-pathological correlation assessment of different stages of classic MF were performed. Results: A total of 118 instances were included (75 classic MF, 26 folliculotropic MF, 9 erythrodermic MF and 8 poikilodermatous MF). Linear/linear-curved vessels and white scales in the skin furrows were significantly associated with patch-stage MF, while clustered dotted vessels were related to plaque-stage MF and peripheral linear vessels with branches, ulceration and red globules separated by white lines to tumour-stage MF. Moreover, patchy white scales were significantly more common in patches and plaques compared to tumours, whereas focal bright white structureless areas were related to plaque and tumoral stage. Vessels histopathologically corresponded to dilated vascular structures in the dermis, orange structureless areas to either dermal hemosiderin (patch/plaque stage) or dense cellular infiltration (tumours), bright white lines/structureless areas to dermal fibrosis and ulceration to loss of epidermis. The main dermoscopic findings of folliculotropic MF were lack of hairs, dilated follicles and follicular plugs, while erythrodermic MF was mainly characterized by linear/dotted vessels, patchy white scales and focal orange structureless areas and poikilodermatous MF by focal white and brown structureless areas, white patchy scales and brown reticular lines. Conclusion: Dermoscopy may allow a more precise characterization of classic MF and reveal clues suggestive of the main MF variants.
KW - dermoscopy
KW - folliculotropic mycosis fungoides
KW - infiltrative dermatoses
KW - lymphomas
KW - mycosis fungoides
UR - http://www.scopus.com/inward/record.url?scp=85127226753&partnerID=8YFLogxK
U2 - 10.1111/jdv.18078
DO - 10.1111/jdv.18078
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 35285088
AN - SCOPUS:85127226753
SN - 0926-9959
VL - 36
SP - 1045
EP - 1053
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 7
ER -
