Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

Lee Goren Zur, Ashgan Bishara, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

Original languageEnglish
Pages (from-to)4487-4509
Number of pages23
JournalMarine Drugs
Volume11
Issue number11
DOIs
StatePublished - Nov 2013

Keywords

  • Fascaplysinopsis sp.
  • Leukemia cells
  • Nitrogenous macrolide
  • Salarins
  • Sponge
  • Tulearins

Fingerprint

Dive into the research topics of 'Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites'. Together they form a unique fingerprint.

Cite this