Derangement in stress response of apolipoprotein E-deficient mice

Irit Gordon, Shamgar Ben-Eliyahu, Ella Rosenne, Ephraim Sehayek, Daniel M. Michaelson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD). Stress has been identified as a putative risk factor of AD. Thus, in the present study we examined the susceptibility of apoE-deficient mice to stress. The results obtained revealed that the elevation of corticosterone levels in apoE-deficient mice following restraint stress is markedly lower than in controls, and that these mice differ in their behavioral pain response to noxious stimuli in both stress and non-stress conditions. These findings suggest an interplay between apoE and the response to stressful stimuli and provide a model for elucidating the relationship between apoE and susceptibility to stress.

Original languageEnglish
Pages (from-to)212-214
Number of pages3
JournalNeuroscience Letters
Issue number2-3
StatePublished - 15 Mar 1996


FundersFunder number
Eichenbaum Foundation


    • Alzheimer's disease
    • Apolipoprotein E
    • Apolipoprotein E-deficient mice
    • Corticosterone
    • Stress


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