Derangement in stress response of apolipoprotein E-deficient mice

Irit Gordon; Shamgar Ben-Eliyahu; Ella Rosenne; Ephraim Sehayek; Daniel M. Michaelson

doi:10.1016/S0304-3940(96)12470-8

Derangement in stress response of apolipoprotein E-deficient mice

Irit Gordon, Shamgar Ben-Eliyahu, Ella Rosenne, Ephraim Sehayek, Daniel M. Michaelson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD). Stress has been identified as a putative risk factor of AD. Thus, in the present study we examined the susceptibility of apoE-deficient mice to stress. The results obtained revealed that the elevation of corticosterone levels in apoE-deficient mice following restraint stress is markedly lower than in controls, and that these mice differ in their behavioral pain response to noxious stimuli in both stress and non-stress conditions. These findings suggest an interplay between apoE and the response to stressful stimuli and provide a model for elucidating the relationship between apoE and susceptibility to stress.

Original language	English
Pages (from-to)	212-214
Number of pages	3
Journal	Neuroscience Letters
Volume	206
Issue number	2-3
DOIs	https://doi.org/10.1016/S0304-3940(96)12470-8
State	Published - 15 Mar 1996

Funding

Funders	Funder number
Eichenbaum Foundation

Keywords

Alzheimer's disease
Apolipoprotein E
Apolipoprotein E-deficient mice
Corticosterone
Stress

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10.1016/S0304-3940(96)12470-8

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title = "Derangement in stress response of apolipoprotein E-deficient mice",

abstract = "Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD). Stress has been identified as a putative risk factor of AD. Thus, in the present study we examined the susceptibility of apoE-deficient mice to stress. The results obtained revealed that the elevation of corticosterone levels in apoE-deficient mice following restraint stress is markedly lower than in controls, and that these mice differ in their behavioral pain response to noxious stimuli in both stress and non-stress conditions. These findings suggest an interplay between apoE and the response to stressful stimuli and provide a model for elucidating the relationship between apoE and susceptibility to stress.",

keywords = "Alzheimer's disease, Apolipoprotein E, Apolipoprotein E-deficient mice, Corticosterone, Stress",

author = "Irit Gordon and Shamgar Ben-Eliyahu and Ella Rosenne and Ephraim Sehayek and Michaelson, {Daniel M.}",

note = "Funding Information: We thank Dr. J.L. Breslow for kindly providing the apoE-deficient and control mice. This work was supported in part by grants to D.M.M. from the Simon Re-vah-Kabelli Fund and from the Eichenbaum Foundation.",

year = "1996",

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doi = "10.1016/S0304-3940(96)12470-8",

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AU - Gordon, Irit

AU - Ben-Eliyahu, Shamgar

AU - Rosenne, Ella

AU - Sehayek, Ephraim

AU - Michaelson, Daniel M.

N1 - Funding Information: We thank Dr. J.L. Breslow for kindly providing the apoE-deficient and control mice. This work was supported in part by grants to D.M.M. from the Simon Re-vah-Kabelli Fund and from the Eichenbaum Foundation.

PY - 1996/3/15

Y1 - 1996/3/15

N2 - Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD). Stress has been identified as a putative risk factor of AD. Thus, in the present study we examined the susceptibility of apoE-deficient mice to stress. The results obtained revealed that the elevation of corticosterone levels in apoE-deficient mice following restraint stress is markedly lower than in controls, and that these mice differ in their behavioral pain response to noxious stimuli in both stress and non-stress conditions. These findings suggest an interplay between apoE and the response to stressful stimuli and provide a model for elucidating the relationship between apoE and susceptibility to stress.

AB - Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD). Stress has been identified as a putative risk factor of AD. Thus, in the present study we examined the susceptibility of apoE-deficient mice to stress. The results obtained revealed that the elevation of corticosterone levels in apoE-deficient mice following restraint stress is markedly lower than in controls, and that these mice differ in their behavioral pain response to noxious stimuli in both stress and non-stress conditions. These findings suggest an interplay between apoE and the response to stressful stimuli and provide a model for elucidating the relationship between apoE and susceptibility to stress.

KW - Alzheimer's disease

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KW - Corticosterone

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Derangement in stress response of apolipoprotein E-deficient mice

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