Depressed PHA transformation and acute leukemia in macroglobulinemia

Albert I. Pick; Michael Eldar; Dan Douer; Zipora Mammon; Yoram Levo; Chaya Weiss; Yehuda Shoenfeld; Jack Pinkhas

doi:10.1002/1097-0142(197911)44:5<1741::AID-CNCR2820440530>3.0.CO;2-%23

Depressed PHA transformation and acute leukemia in macroglobulinemia

Albert I. Pick, Michael Eldar, Dan Douer, Zipora Mammon, Yoram Levo, Chaya Weiss, Yehuda Shoenfeld, Jack Pinkhas^*

^*Corresponding author for this work

Clinical Departments

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Two out of fifty‐three patients with macroglobulinemia developed acute leukemia following chemotherapy. The Phytohemagglutinin (PHA) Transformation Index performed prior to the appearance of acute leukemia was found to be markedly depressed in these two patients in comparison with ten other patients with macroglobulinemia. In addition, a clone with monosomy 7 was detected in one of the currently reported patients when the leukemic process became apparent. The cytogenetic analysis was normal in the same patient 48 months earlier, when macroglobulinemia was diagnosed. The low PHA Transformation Index and the chromosomal hypodiploidy are of interest and their clinical significance merits further investigation.

Original language	English
Pages (from-to)	1741-1744
Number of pages	4
Journal	Cancer
Volume	44
Issue number	5
DOIs	https://doi.org/10.1002/1097-0142(197911)44:5<1741::AID-CNCR2820440530>3.0.CO;2-%23
State	Published - Nov 1979

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10.1002/1097-0142(197911)44:5<1741::AID-CNCR2820440530>3.0.CO;2-%23

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abstract = "Two out of fifty‐three patients with macroglobulinemia developed acute leukemia following chemotherapy. The Phytohemagglutinin (PHA) Transformation Index performed prior to the appearance of acute leukemia was found to be markedly depressed in these two patients in comparison with ten other patients with macroglobulinemia. In addition, a clone with monosomy 7 was detected in one of the currently reported patients when the leukemic process became apparent. The cytogenetic analysis was normal in the same patient 48 months earlier, when macroglobulinemia was diagnosed. The low PHA Transformation Index and the chromosomal hypodiploidy are of interest and their clinical significance merits further investigation.",

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AU - Pick, Albert I.

AU - Eldar, Michael

AU - Douer, Dan

AU - Mammon, Zipora

AU - Levo, Yoram

AU - Weiss, Chaya

AU - Shoenfeld, Yehuda

AU - Pinkhas, Jack

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AB - Two out of fifty‐three patients with macroglobulinemia developed acute leukemia following chemotherapy. The Phytohemagglutinin (PHA) Transformation Index performed prior to the appearance of acute leukemia was found to be markedly depressed in these two patients in comparison with ten other patients with macroglobulinemia. In addition, a clone with monosomy 7 was detected in one of the currently reported patients when the leukemic process became apparent. The cytogenetic analysis was normal in the same patient 48 months earlier, when macroglobulinemia was diagnosed. The low PHA Transformation Index and the chromosomal hypodiploidy are of interest and their clinical significance merits further investigation.

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Depressed PHA transformation and acute leukemia in macroglobulinemia

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