Depressed PHA transformation and acute leukemia in macroglobulinemia

Albert I. Pick, Michael Eldar, Dan Douer, Zipora Mammon, Yoram Levo, Chaya Weiss, Yehuda Shoenfeld, Jack Pinkhas

Research output: Contribution to journalArticlepeer-review


Two out of fifty‐three patients with macroglobulinemia developed acute leukemia following chemotherapy. The Phytohemagglutinin (PHA) Transformation Index performed prior to the appearance of acute leukemia was found to be markedly depressed in these two patients in comparison with ten other patients with macroglobulinemia. In addition, a clone with monosomy 7 was detected in one of the currently reported patients when the leukemic process became apparent. The cytogenetic analysis was normal in the same patient 48 months earlier, when macroglobulinemia was diagnosed. The low PHA Transformation Index and the chromosomal hypodiploidy are of interest and their clinical significance merits further investigation.

Original languageEnglish
Pages (from-to)1741-1744
Number of pages4
Issue number5
StatePublished - Nov 1979


Dive into the research topics of 'Depressed PHA transformation and acute leukemia in macroglobulinemia'. Together they form a unique fingerprint.

Cite this