TY - JOUR
T1 - Depletion of cellular β-hexosaminidase by imipramine is prevented by dexamethasone; implications for treating psychotic hexosaminidase-A deficient patients
AU - Navon, Ruth
AU - Baram, Dana
PY - 1987/11/13
Y1 - 1987/11/13
N2 - Normal human skin fibroblasts secrete most of their hexosaminidase (Hex) into the medium upon incubation with 10-4 M imipramine, while preincubation with 2.5 × 10-9 M dexamethasone prevents this effect. These results support the hypotheses that 1) treatment of psychotic Hex A deficient patients with amphiphilic antidepressants (such as imipramine) aggravates the patients' disease through depletion of their residual cellular Hex A, and 2) concomitant medication with dexamethasone may mitigate this drug-induced deleterious effect.
AB - Normal human skin fibroblasts secrete most of their hexosaminidase (Hex) into the medium upon incubation with 10-4 M imipramine, while preincubation with 2.5 × 10-9 M dexamethasone prevents this effect. These results support the hypotheses that 1) treatment of psychotic Hex A deficient patients with amphiphilic antidepressants (such as imipramine) aggravates the patients' disease through depletion of their residual cellular Hex A, and 2) concomitant medication with dexamethasone may mitigate this drug-induced deleterious effect.
UR - http://www.scopus.com/inward/record.url?scp=0023606614&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(87)80245-0
DO - 10.1016/S0006-291X(87)80245-0
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AN - SCOPUS:0023606614
SN - 0006-291X
VL - 148
SP - 1098
EP - 1103
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -