Depletion of cellular β-hexosaminidase by imipramine is prevented by dexamethasone; implications for treating psychotic hexosaminidase-A deficient patients

Ruth Navon*, Dana Baram

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Normal human skin fibroblasts secrete most of their hexosaminidase (Hex) into the medium upon incubation with 10-4 M imipramine, while preincubation with 2.5 × 10-9 M dexamethasone prevents this effect. These results support the hypotheses that 1) treatment of psychotic Hex A deficient patients with amphiphilic antidepressants (such as imipramine) aggravates the patients' disease through depletion of their residual cellular Hex A, and 2) concomitant medication with dexamethasone may mitigate this drug-induced deleterious effect.

Original languageEnglish
Pages (from-to)1098-1103
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume148
Issue number3
DOIs
StatePublished - 13 Nov 1987

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