TY - JOUR
T1 - Dependence of solute solubility parameters on solvent polarity
AU - Martin, A.
AU - Wu, P. L.
AU - Liron, Z.
AU - Cohen, S.
PY - 1985/6
Y1 - 1985/6
N2 - In nonpolar solvents a solute may self‐associate through polar interactions, exposing its nonpolar surface to a solvent with a low solubility parameter, δ1. In polar solvents a solute in solvated, presumably, by the polar groups of the solvent. This „chameleonic” effect results in different solubility parameters for a solute, depending on the polarity of the solvent. This report presents data for solute solubility parameters in solvents of variable polarity and gives suggestions for dealing with the chameleonic effect associated with solute‐solvent interaction.
AB - In nonpolar solvents a solute may self‐associate through polar interactions, exposing its nonpolar surface to a solvent with a low solubility parameter, δ1. In polar solvents a solute in solvated, presumably, by the polar groups of the solvent. This „chameleonic” effect results in different solubility parameters for a solute, depending on the polarity of the solvent. This report presents data for solute solubility parameters in solvents of variable polarity and gives suggestions for dealing with the chameleonic effect associated with solute‐solvent interaction.
UR - http://www.scopus.com/inward/record.url?scp=0021845931&partnerID=8YFLogxK
U2 - 10.1002/jps.2600740611
DO - 10.1002/jps.2600740611
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AN - SCOPUS:0021845931
SN - 0022-3549
VL - 74
SP - 638
EP - 642
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 6
ER -