Dependence of solute solubility parameters on solvent polarity

A. Martin, P. L. Wu, Z. Liron, S. Cohen

Research output: Contribution to journalArticlepeer-review


In nonpolar solvents a solute may self‐associate through polar interactions, exposing its nonpolar surface to a solvent with a low solubility parameter, δ1. In polar solvents a solute in solvated, presumably, by the polar groups of the solvent. This „chameleonic” effect results in different solubility parameters for a solute, depending on the polarity of the solvent. This report presents data for solute solubility parameters in solvents of variable polarity and gives suggestions for dealing with the chameleonic effect associated with solute‐solvent interaction.

Original languageEnglish
Pages (from-to)638-642
Number of pages5
JournalJournal of Pharmaceutical Sciences
Issue number6
StatePublished - Jun 1985


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