Dental extractions in patients with bleeding disorders. The use of fibrin glue

Meir Rakocz, Avital Mazar, David Varon, Shoshana Spierer, Daniela Blinder, Uri Martinowitz

Research output: Contribution to journalArticlepeer-review

Abstract

Eighty patients with various bleeding disorders underwent 135 extractions without preventive replacement hematologic therapy. The local hemostatic control involved the use of fibrin glue Beriplast. Secondary bleeding occurred in 9 of 12 patients with severe hemophilia when the concentration of the aprotinin in the fibrin glue was 1,000 KIU/ml. When it was increased to 10,000 KIU/ml and swish and swallow rinses of tranexamic acid before and after the dental extractions were added, only 3 of 25 hemophilia patients suffered from secondary bleeding. Local use of fibrin glue is a safe and cost-effective tool to treat patients with severe bleeding disorders. None of the 43 patients with coagulopathies other than severe hemophilia suffered bleeding after extractions.

Original languageEnglish
Pages (from-to)280-282
Number of pages3
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume75
Issue number3
DOIs
StatePublished - Mar 1993
Externally publishedYes

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