Abstract
The mechanism of denervation supersensitivity was investigated, using the pupillary system as an experimental model. A pharmacological study was carried out in six patients with Horner's syndrome due to postganglionic lesions. Administration of cocaine 4% resulted in dilatation of the normal pupil, while subsequent instillation of phenylephrine (2.5 to 5%) produced equal dilatation in both eyes. The results of the study indicate that denervation supersensitivity of the pupil can be explained solely by impaired reabsorption of catecholamines.
| Original language | English |
|---|---|
| Pages (from-to) | 313-319 |
| Number of pages | 7 |
| Journal | Ophthalmologica |
| Volume | 170 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |