Denervation supersensitivity in Horner's syndrome

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The mechanism of denervation supersensitivity was investigated, using the pupillary system as an experimental model. A pharmacological study was carried out in six patients with Horner's syndrome due to postganglionic lesions. Administration of cocaine 4% resulted in dilatation of the normal pupil, while subsequent instillation of phenylephrine (2.5 to 5%) produced equal dilatation in both eyes. The results of the study indicate that denervation supersensitivity of the pupil can be explained solely by impaired reabsorption of catecholamines.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
Issue number4
StatePublished - 1975
Externally publishedYes


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