Demonstration of thymopoietin transcripts in different hematopoietic cell lines

R. Berger; L. Theodor; F. Brok-Simoni; H. Ben-Bassatb; L. Trakhtenbrot; J. Shoham; G. Rechavi

doi:10.1159/000204113

Demonstration of thymopoietin transcripts in different hematopoietic cell lines

R. Berger^*, L. Theodor, F. Brok-Simoni, H. Ben-Bassatb, L. Trakhtenbrot, J. Shoham, G. Rechavi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We have cloned and characterized the human thymopoietin (TP) coding region and studied the mRNA expression of this gene in different hematopoietic cell lines. The 150-bp PCR fragment that encodes the 49-amino-acid human TP peptide was isolated from genomic placental DNA. Its colinearity with the cDNA sequence suggests lack of introns within the coding region. TP mRNA expression was demonstrated in lymphocytes from all the differentiation stages investigated, as well as in a myeloid cell line (K-562). These findings suggest a further expansion of the proposed TP functions.

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Acta Haematologica
Volume	93
Issue number	2-4
DOIs	https://doi.org/10.1159/000204113
State	Published - 1995
Externally published	Yes

Keywords

S1 nuclease
Thymopoietin

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000204113

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title = "Demonstration of thymopoietin transcripts in different hematopoietic cell lines",

abstract = "We have cloned and characterized the human thymopoietin (TP) coding region and studied the mRNA expression of this gene in different hematopoietic cell lines. The 150-bp PCR fragment that encodes the 49-amino-acid human TP peptide was isolated from genomic placental DNA. Its colinearity with the cDNA sequence suggests lack of introns within the coding region. TP mRNA expression was demonstrated in lymphocytes from all the differentiation stages investigated, as well as in a myeloid cell line (K-562). These findings suggest a further expansion of the proposed TP functions.",

keywords = "S1 nuclease, Thymopoietin",

author = "R. Berger and L. Theodor and F. Brok-Simoni and H. Ben-Bassatb and L. Trakhtenbrot and J. Shoham and G. Rechavi",

year = "1995",

doi = "10.1159/000204113",

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volume = "93",

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T1 - Demonstration of thymopoietin transcripts in different hematopoietic cell lines

AU - Berger, R.

AU - Theodor, L.

AU - Brok-Simoni, F.

AU - Ben-Bassatb, H.

AU - Trakhtenbrot, L.

AU - Shoham, J.

AU - Rechavi, G.

PY - 1995

Y1 - 1995

N2 - We have cloned and characterized the human thymopoietin (TP) coding region and studied the mRNA expression of this gene in different hematopoietic cell lines. The 150-bp PCR fragment that encodes the 49-amino-acid human TP peptide was isolated from genomic placental DNA. Its colinearity with the cDNA sequence suggests lack of introns within the coding region. TP mRNA expression was demonstrated in lymphocytes from all the differentiation stages investigated, as well as in a myeloid cell line (K-562). These findings suggest a further expansion of the proposed TP functions.

AB - We have cloned and characterized the human thymopoietin (TP) coding region and studied the mRNA expression of this gene in different hematopoietic cell lines. The 150-bp PCR fragment that encodes the 49-amino-acid human TP peptide was isolated from genomic placental DNA. Its colinearity with the cDNA sequence suggests lack of introns within the coding region. TP mRNA expression was demonstrated in lymphocytes from all the differentiation stages investigated, as well as in a myeloid cell line (K-562). These findings suggest a further expansion of the proposed TP functions.

KW - S1 nuclease

KW - Thymopoietin

UR - http://www.scopus.com/inward/record.url?scp=0029156485&partnerID=8YFLogxK

U2 - 10.1159/000204113

DO - 10.1159/000204113

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AN - SCOPUS:0029156485

SN - 0001-5792

VL - 93

SP - 62

EP - 66

JO - Acta Haematologica

JF - Acta Haematologica

IS - 2-4

ER -

Demonstration of thymopoietin transcripts in different hematopoietic cell lines

Abstract

Keywords

UN SDGs

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