Demonstration of endogenous "imipramine like" material in rat brain

Moshe Rehavi*, Ilana Ventura, Yosef Sarne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The extraction and partial purification of an endogenous "imipramine-like" material from rat brain is described. The endogenous factor obtained after gel filtration and silica chromatography inhibits [3H] imipramine specific binding and mimics the inhibitory effect of imipramine on [3H] serotonin uptake in both brain and platelet preparations. The effects of the endogenous material are dose-dependent and it inhibits [3H] imipramine binding in a competitive fashion. The factor is unevenly distributed in the brain with high concentration in the hypothalamus and low concentration in the cerebellum.

Original languageEnglish
Pages (from-to)687-693
Number of pages7
JournalLife Sciences
Issue number7
StatePublished - 18 Feb 1985


FundersFunder number
Basic Research Foundation of Tel Avlv University
Schrelber Foundation


    Dive into the research topics of 'Demonstration of endogenous "imipramine like" material in rat brain'. Together they form a unique fingerprint.

    Cite this