@article{831b911573204310b2dc73607a4f7ce2,
title = "Demonstration of endogenous {"}imipramine like{"} material in rat brain",
abstract = "The extraction and partial purification of an endogenous {"}imipramine-like{"} material from rat brain is described. The endogenous factor obtained after gel filtration and silica chromatography inhibits [3H] imipramine specific binding and mimics the inhibitory effect of imipramine on [3H] serotonin uptake in both brain and platelet preparations. The effects of the endogenous material are dose-dependent and it inhibits [3H] imipramine binding in a competitive fashion. The factor is unevenly distributed in the brain with high concentration in the hypothalamus and low concentration in the cerebellum.",
author = "Moshe Rehavi and Ilana Ventura and Yosef Sarne",
note = "Funding Information: Thls research was supported by grants from the Basic Research Foundation of Tel Avlv University to M.R. and from the Schrelber Foundation to Y.S.",
year = "1985",
month = feb,
day = "18",
doi = "10.1016/0024-3205(85)90174-2",
language = "אנגלית",
volume = "36",
pages = "687--693",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "7",
}