Demonstration of a saturable binding site for thyrotropin in yersinia enterocolitica

Mordechai Weiss, Sidney H. Ingbar, Sten Winblad, Dennis L. Kasper

Research output: Contribution to journalArticlepeer-review

Abstract

Several lines of evidence suggest that there might be immunologic cross-reactivity between the thyroid plasma membrane in humans and antigenic determinants in the enteric pathogen Yersinia enterocolitica. Studies were therefore performed to determine whether Y. enterocolitica, like the thyroid membrane, contains a thyrotropin binding site. A saturable binding site for bovine thyrotropin was indeed demonstrable, particularly in preparations of the organism that have been treated with ethylenediaminetetraacetate and lysozyme. Hormonal specificity of the binding site, as judged from the inhibition of binding of 125I-labeled bovine thyrotropin, was similar to that of the thyrotropin receptor in human thyroid tissue.

Original languageEnglish
Pages (from-to)1327-1328
Number of pages2
JournalScience
Volume219
Issue number4590
DOIs
StatePublished - 1983
Externally publishedYes

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