Delta and kappa opioid receptors in eyestalk ganglia of a crustacean

Joachim Hanke, Axel Willig, Uri Yinon, Peter P. Jaros

Research output: Contribution to journalArticlepeer-review


Crustacean eyestalk ganglia are part of the protocerebrum and have been demonstrated to produce numerous neurohormones. 3H(2-D-Pen, 5-D-Pen)-enkephalin, 3H-(-)-ethylketocyclazocine and 3H(D-Ala2-NMePhe-Glyol5)-enkephalin were used as ligands for opioid receptors on neuronal membrane preparations of eyestalk ganglia under consideration of their stereospecific binding properties. In context with saturation binding isotherms, association and dissociation plots, we demonstrate here two opioid receptors: a delta-type receptor with high affinity (B(max) 68.5 fmol/mg protein, K(d) = 4.0 nM) and low affinity (B(max) 493 fmol/mg, K(d) = 83.6 nM) and a second receptor of kappa-type with B(max) of 3.1 pmol/mg protein and K(d) = 68.6 nM.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBrain Research
Issue number2
StatePublished - 9 Jan 1997


  • crustacea
  • enkephalin
  • eyestalk ganglion
  • opioid receptor subtype
  • radioligand binding


Dive into the research topics of 'Delta and kappa opioid receptors in eyestalk ganglia of a crustacean'. Together they form a unique fingerprint.

Cite this