Delivery of therapeutic aerosols to intubated babies

Jonathan Grigg, Shmuel Arnon, Tracey Jones, Andrew Clarke, Michael Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Delivery of drug aerosols to the lungs of ventilated neonates by metered dose inhaler and spacer (Aerochamber) and ultrasonic nebuliser (Pentasonic) was assessed using sodium cromoglycate. The mean proportion of a known intratracheal dose ofsodium cromoglycate excreted in the urine of four intubated infants was 37.5%. After assuming that 38% of the sodium cromoglycate aerosol reaching the neonatal lung will be excreted in the urine, three puffs (15 mg) delivered by metered dose inhaler and spacer resulted in a pulmonary dose of 258μg (1.7%, n=7). A close of 20 mg (4 ml) sodium cromoglycate ultrasonically nebulised over five minutes into the inspiratory limb of a standard ventilator circuit produced a pulmonary dose of 257μg (1.3%, n=7). Of two in vitro lung models assessed, a combination of filter and neonatal test lung was superior to a multistage impactor in estimating the in vivo pulmonary sodium cromoglycate dose delivered by metered dose inhaler and spacer (243μg v 1740 μg).

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalArchives of Disease in Childhood
Volume67
Issue number1 SPEC NO
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Dive into the research topics of 'Delivery of therapeutic aerosols to intubated babies'. Together they form a unique fingerprint.

Cite this