Delivery of micronized budesonide suspension by metered dose inhaler and jet nebulizer into a neonatal ventilator circuit

S. Arnon, J. Grigg, K. Nikander, M. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

We compared the delivery of a micronized suspension of budesonide by a metered dose inhaler (MDI) with two different spacers (Aerochamber and Aerovent) and by two jet nebulizers (MAD2 and Ultravent) to a ventilated neonatal test‐lung using a standard neonatal ventilator circuit. The combination of MDI and Aerochamber was significantly better at delivering budesonide to a filter in front of the test lung (14.2% of aerosolized dose) than were either the MDI and Aerovent (3.6%) or the Ultravent or MAD2 jet nebulizers (0.02% and 0.68% of initial reservoir dose). Of the droplets emerging from the MDI, Aerochamber, and ET tube, 18% of the initial dose was in droplets < 4.7 μm. Assuming that the test‐lung model accurately reflects in vivo deposition, the combination of MDI and Aerochamber appears to be an extremely effective way of delivering budesonide aerosol to ventilated newborn infants. © 1992 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalPediatric Pulmonology
Volume13
Issue number3
DOIs
StatePublished - Jul 1992
Externally publishedYes

Keywords

  • Test‐lung model
  • delivered dose percent
  • droplet size

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