Delivery mode and future infectious morbidity of the offspring: a sibling analysis

Purpose: Cesarean delivery (CD) has been recently suggested to be associated with offspring’s long-term health implications. We aimed to investigate the association between delivery mode and long-term infectious morbidity of the offspring while employing sibling matched analysis to maximize confounder control. Methods: A retrospective population-based cohort study was performed, which included all sibling deliveries occurring between 1991 and 2014 at a regional tertiary medical center. Offsprings were followed up until the age of 18 years. The study included 13,516 individuals (6758 sibling pairs): the first born was via vaginal delivery and the second via CD. Each siblings pair was considered a matched set, with the aim to perform a within-family analysis. A Kaplan–Meier survival curve was used to compare the cumulative infectious morbidity incidence and a multivariable Cox survival hazards regression model to control for confounders. Results: Crude rates of total infectious hospitalizations were found to be significantly higher in the CD group (OR 1.25; 95% CI 1.12–1.40). Specifically, bronchiolitis (OR 2.02, 95% CI 1.56–2.63), otitis (OR 1.52, 95% CI 1.21–1.9), and gastroenteritis (OR 1.41, 95% CI 1.05–1.9) were all found to be significantly more common in the CD group. The survival curve demonstrated significantly higher cumulative infection-related hospitalization rates in the CD group (log-rank p < 0.001). The Cox model, adjusted for several confounders, confirmed the significant association between CD and offspring’s infection-related morbidity (adjusted HR 1.25; 95% CI 1.02–1.53). Conclusion: CD appears to be independently associated with later offspring infection-related morbidity, even while rigorously adjusting for confounders.