Delivering bioactive molecules as instructive cues to engineered tissues

Doris Gabriel, Tal Dvir, Daniel S. Kohane*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction : Growth factors and other bioactive molecules play a crucial role in the creation of functional engineered tissues from dissociated cells. Areas covered : This review discusses the delivery of bioactive molecules particularly growth factors to affect cellular function in the context of tissue engineering. We discuss the primary biological themes that are addressed by delivering bioactives, the types of molecules that are to be delivered, the major materials used in producing scaffolds and/or drug delivery systems, and the principal drug delivery strategies. Expert opinion : Drug delivery systems have allowed the sustained release of bioactive molecules to engineered tissues, with marked effects on tissue function. Sophisticated drug delivery techniques will allow precise recapitulation of developmental milestones by providing temporally distinct patterns of release of multiple bioactives. High-resolution patterning techniques will allow tissue constructs to be designed with precisely defined areas where bioactives can act. New biological discoveries, just as the development of small molecules with potent effects on cell differentiation, will likely have a marked impact on the field.

Original languageEnglish
Pages (from-to)473-492
Number of pages20
JournalExpert Opinion on Drug Delivery
Volume9
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Biomaterials
  • Drug delivery
  • Growth factors
  • Tissue engineering

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