Delayed thrombocytopenia following abciximab therapy

Edo Kaluski*, Marina Leitman, Inna Khiger, Gad Cotter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Inhibitors of glycoprotein (GP) IIb/IIIa are currently approved for the treatment of acute coronary syndromes and during performance of percutaneous coronary interventions (PCIs). More than 500 000 patients annually undergo PCIs in the USA alone. Of these, 35% are receiving GPIIb/IIIa inhibitors. Currently, three different intravenous GPIIb/IIIa inhibitors are commercially available. Profound thrombocytopenia occurs almost exclusively with abciximab. Usually thrombocytopenia develops within 24 hours following abciximab administration. This paper describes three patients who developed delayed profound thrombocytopenia, occurring five days following abciximab therapy. These cases of thrombocytopenia were self-limited and reversible. Absence of serious bleeding complications was noted. The pathophysiology, differential diagnosis, natural history and management of the coronary patients with abciximab-induced thrombocytopenia are discussed.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalInternational Journal of Cardiovascular Interventions
Volume4
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Abciximab
  • Glycoprotein
  • Platelets
  • Thrombocytopenia

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