Degradation of cell-bound antibodies by tumor cells from C57BL/6 mice

Yona Keisari, Isaac P. Witz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A kinetic study of the disappearance of sensitizing antibody from metabolizing EL 4 cells in C57BL/6 mice revealed that this disappearance was at least partly due to the degradation of the antibody into dialyzable products. The degradation took place at 37° C, but not at 4° C, and occurred on or inside the cell. The process was specific inasmuch as only those IgG molecules that could bind to the cells were degraded, whereas unrelated third-party antibodies present in the culture medium remained intact. Although nonmalignant ceils also have the capacity to degrade cell-bound antibodies, possibly the degradation of proteinaceous structures on antitumor effector mechanisms is, in part, responsible for decreased antitumor immunity.

Original languageEnglish
Pages (from-to)1135-1141
Number of pages7
JournalJournal of the National Cancer Institute
Issue number4
StatePublished - Oct 1978


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