TY - JOUR
T1 - Degradation of cell-bound antibodies by tumor cells from C57BL/6 mice
AU - Keisari, Yona
AU - Witz, Isaac P.
PY - 1978/10
Y1 - 1978/10
N2 - A kinetic study of the disappearance of sensitizing antibody from metabolizing EL 4 cells in C57BL/6 mice revealed that this disappearance was at least partly due to the degradation of the antibody into dialyzable products. The degradation took place at 37° C, but not at 4° C, and occurred on or inside the cell. The process was specific inasmuch as only those IgG molecules that could bind to the cells were degraded, whereas unrelated third-party antibodies present in the culture medium remained intact. Although nonmalignant ceils also have the capacity to degrade cell-bound antibodies, possibly the degradation of proteinaceous structures on antitumor effector mechanisms is, in part, responsible for decreased antitumor immunity.
AB - A kinetic study of the disappearance of sensitizing antibody from metabolizing EL 4 cells in C57BL/6 mice revealed that this disappearance was at least partly due to the degradation of the antibody into dialyzable products. The degradation took place at 37° C, but not at 4° C, and occurred on or inside the cell. The process was specific inasmuch as only those IgG molecules that could bind to the cells were degraded, whereas unrelated third-party antibodies present in the culture medium remained intact. Although nonmalignant ceils also have the capacity to degrade cell-bound antibodies, possibly the degradation of proteinaceous structures on antitumor effector mechanisms is, in part, responsible for decreased antitumor immunity.
UR - http://www.scopus.com/inward/record.url?scp=0018071839&partnerID=8YFLogxK
U2 - 10.1093/jnci/61.4.1135
DO - 10.1093/jnci/61.4.1135
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AN - SCOPUS:0018071839
SN - 0027-8874
VL - 61
SP - 1135
EP - 1141
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 4
ER -