Degradation mechanism of 2,4-dichlorophenol by fungi isolated from marine invertebrates

Efstratios Nikolaivits, Andreas Agrafiotis, Eirini Baira, Géraldine Le Goff, Nikolaos Tsafantakis, Suchana A. Chavanich, Yehuda Benayahu, Jamal Ouazzani, Nikolas Fokialakis, Evangelos Topakas

Research output: Contribution to journalArticlepeer-review

Abstract

2,4-Dichlorophenol (2,4-DCP) is a ubiquitous environmental pollutant categorized as a priority pollutant by the United States (US) Environmental Protection Agency, posing adverse health effects on humans and wildlife. Bioremediation is proposed as an eco-friendly, cost-effective alternative to traditional physicochemical remediation techniques. In the present study, fungal strains were isolated from marine invertebrates and tested for their ability to biotransform 2,4-DCP at a concentration of 1 mM. The most competent strains were studied further for the expression of catechol dioxygenase activities and the produced metabolites. One strain, identified as Tritirachium sp., expressed high levels of extracellular catechol 1,2-dioxygenase activity. The same strain also produced a dechlorinated cleavage product of the starting compound, indicating the assimilation of the xenobiotic by the fungus. This work also enriches the knowledge about the mechanisms employed by marine-derived fungi in order to defend themselves against chlorinated xenobiotics.

Original languageEnglish
Article number3317
JournalInternational Journal of Molecular Sciences
Volume21
Issue number9
DOIs
StatePublished - 1 May 2020

Keywords

  • 2,4-dichlorophenol
  • Catechol dioxygenase
  • DCP metabolites
  • Invertebrate symbionts
  • Marine-derived fungi

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