Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Dedee F. Murrell; Branka Marinovic; Frederic Caux; Catherine Prost; Razzaque Ahmed; Katarzyna Wozniak; Masayuki Amagai; Johann Bauer; Stefan Beissert; Luca Borradori; Donna Culton; Janet A. Fairley; David Fivenson; Marcel F. Jonkman; M. Peter Marinkovich; David Woodley; John Zone; Valeria Aoki; Philippe Bernard; Leen Bruckner-Tuderman; Giuseppe Cianchini; Vanessa Venning; Luis Diaz; Rudiger Eming; Sergei A. Grando; Russell P. Hall; Takashi Hashimoto; Josep E. Herrero-González; Michael Hertl; Pascal Joly; Sarolta Karpati; Jaehwan Kim; Soo Chan Kim; Neil J. Korman; Cezary Kowalewski; Sang Eun Lee; David R. Rubenstein; Eli Sprecher; Kim Yancey; Giovann Zambruno; Detlef Zillikens; Serge Doan; Benjamin S. Daniel; Victoria P. Werth

doi:10.1016/j.jaad.2014.08.024

Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Dedee F. Murrell^*
, Branka Marinovic
, Frederic Caux
, Catherine Prost
, Razzaque Ahmed
, Katarzyna Wozniak
, Masayuki Amagai
, Johann Bauer
, Stefan Beissert
, Luca Borradori
, Donna Culton
, Janet A. Fairley
, David Fivenson
, Marcel F. Jonkman
, M. Peter Marinkovich
, David Woodley
, John Zone
, Valeria Aoki
, Philippe Bernard
, Leen Bruckner-Tuderman

Giuseppe Cianchini, Vanessa Venning, Luis Diaz, Rudiger Eming, Sergei A. Grando, Russell P. Hall, Takashi Hashimoto, Josep E. Herrero-González, Michael Hertl, Pascal Joly, Sarolta Karpati, Jaehwan Kim, Soo Chan Kim, Neil J. Korman, Cezary Kowalewski, Sang Eun Lee, David R. Rubenstein, Eli Sprecher, Kim Yancey, Giovann Zambruno, Detlef Zillikens, Serge Doan, Benjamin S. Daniel, Victoria P. Werth

^*Corresponding author for this work

University of New South Wales
University of Zagreb
Université Paris 13
Center for Blistering Diseases
Medical University of Warsaw
Keio University
Paracelsus Private Medical University
Technische Universität Dresden
University of Bern
University of North Carolina at Chapel Hill
University of Iowa
Department of Veterans Affairs
Trinity Health Michigan
University of Groningen
Stanford University
University of Southern California
University of Utah
Universidade de São Paulo
CHU de Reims
University of Freiburg
IRCCS Istituto Dermopatico dell'Immacolata - Roma
Oxford University Hospitals NHS Foundation Trust
University of Marburg
University of California at Irvine
Duke University
Kurume University
Municipal Institute for Medical Research Hospital del Mar
CHU Hôpitaux de Rouen
Semmelweis University
Rockefeller University
Yonsei University
Case Western Reserve University
CHA University
Tel Aviv Sourasky Medical Center
University of Texas Southwestern Medical Center
University of Lübeck
Université Paris Cité
Fondation A de Rothschild
University of Pennsylvania

Research output: Contribution to journal › Review article › peer-review

137 Scopus citations

Abstract

Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.

Original language	English
Pages (from-to)	168-174
Number of pages	7
Journal	Journal of the American Academy of Dermatology
Volume	72
Issue number	1
DOIs	https://doi.org/10.1016/j.jaad.2014.08.024
State	Published - 1 Jan 2015
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health	NIH K24-AR 02207
National Institute of Arthritis and Musculoskeletal and Skin Diseases	K24AR002207
U.S. Department of Veterans Affairs
Office of Research and Development
Health Services Research and Development
Biomedical Laboratory Research and Development, VA Office of Research and Development

Keywords

consensus
definitions
mucous membrane pemphigoid
outcome measures
severity score

Access to Document

10.1016/j.jaad.2014.08.024

Cite this

Murrell, D. F., Marinovic, B., Caux, F., Prost, C., Ahmed, R., Wozniak, K., Amagai, M., Bauer, J., Beissert, S., Borradori, L., Culton, D., Fairley, J. A., Fivenson, D., Jonkman, M. F., Marinkovich, M. P., Woodley, D., Zone, J., Aoki, V., Bernard, P., ... Werth, V. P. (2015). Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts. Journal of the American Academy of Dermatology, 72(1), 168-174. https://doi.org/10.1016/j.jaad.2014.08.024

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title = "Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts",

abstract = "Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.",

keywords = "consensus, definitions, mucous membrane pemphigoid, outcome measures, severity score",

author = "Murrell, \{Dedee F.\} and Branka Marinovic and Frederic Caux and Catherine Prost and Razzaque Ahmed and Katarzyna Wozniak and Masayuki Amagai and Johann Bauer and Stefan Beissert and Luca Borradori and Donna Culton and Fairley, \{Janet A.\} and David Fivenson and Jonkman, \{Marcel F.\} and Marinkovich, \{M. Peter\} and David Woodley and John Zone and Valeria Aoki and Philippe Bernard and Leen Bruckner-Tuderman and Giuseppe Cianchini and Vanessa Venning and Luis Diaz and Rudiger Eming and Grando, \{Sergei A.\} and Hall, \{Russell P.\} and Takashi Hashimoto and Herrero-Gonz{\'a}lez, \{Josep E.\} and Michael Hertl and Pascal Joly and Sarolta Karpati and Jaehwan Kim and \{Chan Kim\}, Soo and Korman, \{Neil J.\} and Cezary Kowalewski and Lee, \{Sang Eun\} and Rubenstein, \{David R.\} and Eli Sprecher and Kim Yancey and Giovann Zambruno and Detlef Zillikens and Serge Doan and Daniel, \{Benjamin S.\} and Werth, \{Victoria P.\}",

note = "Publisher Copyright: {\textcopyright} 2014 American Academy of Dermatology, Inc.",

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doi = "10.1016/j.jaad.2014.08.024",

language = "אנגלית",

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Murrell, DF, Marinovic, B, Caux, F, Prost, C, Ahmed, R, Wozniak, K, Amagai, M, Bauer, J, Beissert, S, Borradori, L, Culton, D, Fairley, JA, Fivenson, D, Jonkman, MF, Marinkovich, MP, Woodley, D, Zone, J, Aoki, V, Bernard, P, Bruckner-Tuderman, L, Cianchini, G, Venning, V, Diaz, L, Eming, R, Grando, SA, Hall, RP, Hashimoto, T, Herrero-González, JE, Hertl, M, Joly, P, Karpati, S, Kim, J, Chan Kim, S, Korman, NJ, Kowalewski, C, Lee, SE, Rubenstein, DR, Sprecher, E, Yancey, K, Zambruno, G, Zillikens, D, Doan, S, Daniel, BS & Werth, VP 2015, 'Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts', Journal of the American Academy of Dermatology, vol. 72, no. 1, pp. 168-174. https://doi.org/10.1016/j.jaad.2014.08.024

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AU - Murrell, Dedee F.

AU - Marinovic, Branka

AU - Caux, Frederic

AU - Prost, Catherine

AU - Ahmed, Razzaque

AU - Wozniak, Katarzyna

AU - Amagai, Masayuki

AU - Bauer, Johann

AU - Beissert, Stefan

AU - Borradori, Luca

AU - Culton, Donna

AU - Fairley, Janet A.

AU - Fivenson, David

AU - Jonkman, Marcel F.

AU - Marinkovich, M. Peter

AU - Woodley, David

AU - Zone, John

AU - Aoki, Valeria

AU - Bernard, Philippe

AU - Bruckner-Tuderman, Leen

AU - Cianchini, Giuseppe

AU - Venning, Vanessa

AU - Diaz, Luis

AU - Eming, Rudiger

AU - Grando, Sergei A.

AU - Hall, Russell P.

AU - Hashimoto, Takashi

AU - Herrero-González, Josep E.

AU - Hertl, Michael

AU - Joly, Pascal

AU - Karpati, Sarolta

AU - Kim, Jaehwan

AU - Chan Kim, Soo

AU - Korman, Neil J.

AU - Kowalewski, Cezary

AU - Lee, Sang Eun

AU - Rubenstein, David R.

AU - Sprecher, Eli

AU - Yancey, Kim

AU - Zambruno, Giovann

AU - Zillikens, Detlef

AU - Doan, Serge

AU - Daniel, Benjamin S.

AU - Werth, Victoria P.

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AB - Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.

KW - consensus

KW - definitions

KW - mucous membrane pemphigoid

KW - outcome measures

KW - severity score

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JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 1

ER -

Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Abstract

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Keywords

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