TY - JOUR
T1 - Deferoxamine (desferal)r - induced ocular toxicity
AU - Kaplinsky, C.
AU - Stark, B.
AU - Goshen, Y.
AU - Yaniv, I.
AU - Bashara, S.
AU - Zaizov, R.
PY - 1988
Y1 - 1988
N2 - A 4-year-old girl with juvenile chronic myeloid leukemia relapsed after an allogeneic bone marrow transplantation (BMT) and became refractory to conventional chemotherapy. Treatment with two courses of high-dose deferoxamine, an iron chelator (130-180 mg/kg/day), along with low-dose ARA-c (5 mg/kg/day) caused a remarkable decrease of the WBC and fetal Hb. Three days following the last dose of deferoxamine, the patient experienced an acute visual loss, confirmed by electroretinogram (ERG) and visual evoked response (VER). Slight improvement occurred a few days later, but the patient developed severe pancytopenia and died of Klebsiella septic shock. The ocular manifestations were attributed to deferoxamine toxicity in light of the rapid onset after first exposure, the electrophysiological pattern of metabolic damage in the ERG and VER, and the long interval between the last chemotherapy and BMT. The pathogenesis of deferoxamine toxicity is discussed.
AB - A 4-year-old girl with juvenile chronic myeloid leukemia relapsed after an allogeneic bone marrow transplantation (BMT) and became refractory to conventional chemotherapy. Treatment with two courses of high-dose deferoxamine, an iron chelator (130-180 mg/kg/day), along with low-dose ARA-c (5 mg/kg/day) caused a remarkable decrease of the WBC and fetal Hb. Three days following the last dose of deferoxamine, the patient experienced an acute visual loss, confirmed by electroretinogram (ERG) and visual evoked response (VER). Slight improvement occurred a few days later, but the patient developed severe pancytopenia and died of Klebsiella septic shock. The ocular manifestations were attributed to deferoxamine toxicity in light of the rapid onset after first exposure, the electrophysiological pattern of metabolic damage in the ERG and VER, and the long interval between the last chemotherapy and BMT. The pathogenesis of deferoxamine toxicity is discussed.
KW - Deferoxamine
KW - Juvenile CML
KW - Optic neuropathy
UR - http://www.scopus.com/inward/record.url?scp=0023817984&partnerID=8YFLogxK
U2 - 10.3109/08880018809037369
DO - 10.3109/08880018809037369
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AN - SCOPUS:0023817984
SN - 0888-0018
VL - 5
SP - 293
EP - 297
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 4
ER -