Defective regulation of HMG-CoA reductase degradation in the lovastatin-resistant L-90 cells

Keyphrases

• Lovastatin 100%
• HMG-CoA Reductase 100%
• Mevalonate 62%
• Sterols 50%
• Reticulum 25%
• Transmembrane Domain 25%
• Overexpressing 12%
• Rate-limiting Step 12%
• Gene Amplification 12%
• Cholesterol 12%
• Biosynthetic Pathway 12%
• Glycoprotein 12%
• Cellular Level 12%
• Statins 12%
• Cellular Factors 12%
• Fusion Protein 12%
• Chinese Hamster Ovary Cells 12%
• Potent Inhibitor 12%
• β-Galactosidase (β-Gal) 12%
• Immunoprecipitates 12%
• Resistant Cell Lines 12%
• Isoprenoids 12%
• Abnormal Phenotype 12%
• Acting Factor 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Mevinolin 100%
• Hydroxymethylglutaryl Coenzyme A Reductase 100%
• Mevalonic Acid 62%
• Sterol 50%
• Glycoprotein 12%
• Chinese Hamster 12%
• Statin (Protein) 12%
• Galactosidase 12%
• Chimeric Protein 12%
• Isoprenoid 12%
• Liothyronine 12%

Biochemistry, Genetics and Molecular Biology

• Lovastatin 100%
• HMG-CoA Reductase 100%
• Sterol 50%
• Enzyme 25%
• Anabolism 12%
• Glycoprotein 12%
• Gene Amplification 12%
• Immunoprecipitation 12%
• Chinese Hamster 12%
• Statin 12%
• Liothyronine 12%
• Triiodothyronine 12%
• Chimeric Protein 12%
• Galactosidase 12%