Decreased serum tuftsin concentrations in sickle cell disease

Z. Spirer, Y. Weisman, V. Zakuth, M. Fridkin, N. Bogair

Research output: Contribution to journalArticlepeer-review

Abstract

The serum concentrations of the phagocytosis-stimulating peptide, tuftsin, were determined by radioimmunoassay in 21 patients with sickle cell disease and in 12 healthy controls. The mean serum tuftsin concentration was significantly lower in patients with haemoglobin SS disease (154.3 ± 35.1 ng/ml; 308.6 ± 70.2 nmol/l, P <0.01) and in patients with haemoglobin SC and CC disease (180.9 ± 42.7 ng/ml; 361.8 ± 85.4 nmol/l, P <0.05) than in healthy controls (228.7 ± 46.7 ng/ml; 457.4 ± 93.4 nmol/l). Tuftsin deficiency is an indicator of splenic hypofunction and may contribute to the increased susceptibility of patients with sickle cell disease to severe infection.

Original languageEnglish
Pages (from-to)566-567
Number of pages2
JournalArchives of Disease in Childhood
Volume55
Issue number7
DOIs
StatePublished - 1980

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