Decreased platelet imipramine binding in tourette syndrome children with obsessive-compulsive disorder

Abraham Weizman, Anda Mandel, Yerachmiel Barber, Raphael Weitz, Adi Cohen, Roberto Mester, Moshe Rehavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

[3H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects. The density of [3H]imipramine binding sites in TS+OCD patients was significantly lower compared with TS-OCD patients (28%) as well as when compared with controls (31%). This alteration was not accompanied by differences in the affinity of the binding site to the ligand. The decreased density of the platelet serotonin "transporter" might implicate the involvement of the serotonergic system in the pathophysiology of OCD in TS patients, but not in TS per se.

Original languageEnglish
Pages (from-to)705-711
Number of pages7
JournalBiological Psychiatry
Volume31
Issue number7
DOIs
StatePublished - 1 Apr 1992

Funding

FundersFunder number
Tourette Syndrome Association

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