Decreased platelet imipramine binding in tourette syndrome children with obsessive-compulsive disorder

Abraham Weizman; Anda Mandel; Yerachmiel Barber; Raphael Weitz; Adi Cohen; Roberto Mester; Moshe Rehavi

doi:10.1016/0006-3223(92)90280-D

Decreased platelet imipramine binding in tourette syndrome children with obsessive-compulsive disorder

Abraham Weizman, Anda Mandel, Yerachmiel Barber, Raphael Weitz, Adi Cohen, Roberto Mester, Moshe Rehavi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

[³H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects. The density of [³H]imipramine binding sites in TS+OCD patients was significantly lower compared with TS-OCD patients (28%) as well as when compared with controls (31%). This alteration was not accompanied by differences in the affinity of the binding site to the ligand. The decreased density of the platelet serotonin "transporter" might implicate the involvement of the serotonergic system in the pathophysiology of OCD in TS patients, but not in TS per se.

Original language	English
Pages (from-to)	705-711
Number of pages	7
Journal	Biological Psychiatry
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/0006-3223(92)90280-D
State	Published - 1 Apr 1992

Funding

Funders	Funder number
Tourette Syndrome Association

Access to Document

10.1016/0006-3223(92)90280-D

Cite this

@article{11832660d3874a04871d1e2fa3893893,

title = "Decreased platelet imipramine binding in tourette syndrome children with obsessive-compulsive disorder",

abstract = "[3H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects. The density of [3H]imipramine binding sites in TS+OCD patients was significantly lower compared with TS-OCD patients (28%) as well as when compared with controls (31%). This alteration was not accompanied by differences in the affinity of the binding site to the ligand. The decreased density of the platelet serotonin {"}transporter{"} might implicate the involvement of the serotonergic system in the pathophysiology of OCD in TS patients, but not in TS per se.",

author = "Abraham Weizman and Anda Mandel and Yerachmiel Barber and Raphael Weitz and Adi Cohen and Roberto Mester and Moshe Rehavi",

note = "Funding Information: This research was supportedb y a grant from the Tourette Syndrome Association( Bayside, NY).",

year = "1992",

month = apr,

day = "1",

doi = "10.1016/0006-3223(92)90280-D",

language = "אנגלית",

volume = "31",

pages = "705--711",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Decreased platelet imipramine binding in tourette syndrome children with obsessive-compulsive disorder

AU - Weizman, Abraham

AU - Mandel, Anda

AU - Barber, Yerachmiel

AU - Weitz, Raphael

AU - Cohen, Adi

AU - Mester, Roberto

AU - Rehavi, Moshe

N1 - Funding Information: This research was supportedb y a grant from the Tourette Syndrome Association( Bayside, NY).

PY - 1992/4/1

Y1 - 1992/4/1

N2 - [3H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects. The density of [3H]imipramine binding sites in TS+OCD patients was significantly lower compared with TS-OCD patients (28%) as well as when compared with controls (31%). This alteration was not accompanied by differences in the affinity of the binding site to the ligand. The decreased density of the platelet serotonin "transporter" might implicate the involvement of the serotonergic system in the pathophysiology of OCD in TS patients, but not in TS per se.

AB - [3H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects. The density of [3H]imipramine binding sites in TS+OCD patients was significantly lower compared with TS-OCD patients (28%) as well as when compared with controls (31%). This alteration was not accompanied by differences in the affinity of the binding site to the ligand. The decreased density of the platelet serotonin "transporter" might implicate the involvement of the serotonergic system in the pathophysiology of OCD in TS patients, but not in TS per se.

UR - http://www.scopus.com/inward/record.url?scp=0026693355&partnerID=8YFLogxK

U2 - 10.1016/0006-3223(92)90280-D

DO - 10.1016/0006-3223(92)90280-D

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0026693355

SN - 0006-3223

VL - 31

SP - 705

EP - 711

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 7

ER -

Decreased platelet imipramine binding in tourette syndrome children with obsessive-compulsive disorder

Abstract

Funding

Access to Document

Other files and links

Fingerprint

Cite this