TY - JOUR
T1 - Decreased peripheral benzodiazepine binding sites in platelets of neuroleptic-treated schizophrenics
AU - Gavish, Moshe
AU - Weizman, Abraham
AU - Karp, Leon
AU - Tyano, Sam
AU - Tanne, Zehava
PY - 1986/2/18
Y1 - 1986/2/18
N2 - A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healty volunteers. The equilibrium dissociation constant for binding by [3H]PK 11195, which is a ligand specific for peripheral benzodiazepine binding sites, was similar in all three groups. The relevance of the reduction in peripheral-type benzodiazepine binding sites to central or peripheral side-effects induced by long-term neuroleptic treatment merits further investigation.
AB - A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healty volunteers. The equilibrium dissociation constant for binding by [3H]PK 11195, which is a ligand specific for peripheral benzodiazepine binding sites, was similar in all three groups. The relevance of the reduction in peripheral-type benzodiazepine binding sites to central or peripheral side-effects induced by long-term neuroleptic treatment merits further investigation.
KW - Neuroleptics
KW - Peripheral benzodiazepine binding sites
KW - Schizophrenia
KW - [H]PK 11195
UR - http://www.scopus.com/inward/record.url?scp=0022627568&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(86)90500-5
DO - 10.1016/0014-2999(86)90500-5
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AN - SCOPUS:0022627568
VL - 121
SP - 275
EP - 279
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -