Decreased peripheral benzodiazepine binding sites in platelets of neuroleptic-treated schizophrenics

Moshe Gavish, Abraham Weizman, Leon Karp, Sam Tyano, Zehava Tanne

Research output: Contribution to journalArticlepeer-review

Abstract

A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healty volunteers. The equilibrium dissociation constant for binding by [3H]PK 11195, which is a ligand specific for peripheral benzodiazepine binding sites, was similar in all three groups. The relevance of the reduction in peripheral-type benzodiazepine binding sites to central or peripheral side-effects induced by long-term neuroleptic treatment merits further investigation.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalEuropean Journal of Pharmacology
Volume121
Issue number2
DOIs
StatePublished - 18 Feb 1986

Keywords

  • Neuroleptics
  • Peripheral benzodiazepine binding sites
  • Schizophrenia
  • [H]PK 11195

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