Decreased aperiodic neural activity in Parkinson’s disease and dementia with Lewy bodies

Yevgenia Rosenblum, Tamara Shiner, Noa Bregman, Nir Giladi, Inbal Maidan, Firas Fahoum, Anat Mirelman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Neural oscillations and signal complexity have been widely studied in neurodegenerative diseases, whereas aperiodic activity has not been explored yet in those disorders. Here, we assessed whether the study of aperiodic activity brings new insights relating to disease as compared to the conventional spectral and complexity analyses. Eyes-closed resting-state electroencephalography (EEG) was recorded in 21 patients with dementia with Lewy bodies (DLB), 28 patients with Parkinson’s disease (PD), 27 patients with mild cognitive impairment (MCI) and 22 age-matched healthy controls. Spectral power was differentiated into its oscillatory and aperiodic components using the Irregularly Resampled Auto-Spectral Analysis. Signal complexity was explored using the Lempel–Ziv algorithm (LZC). We found that DLB patients showed steeper slopes of the aperiodic power component with large effect sizes compared to the controls and MCI and with a moderate effect size compared to PD. PD patients showed steeper slopes with a moderate effect size compared to controls and MCI. Oscillatory power and LZC differentiated only between DLB and other study groups and were not sensitive enough to detect differences between PD, MCI, and controls. In conclusion, both DLB and PD are characterized by alterations in aperiodic dynamics, which are more sensitive in detecting disease-related neural changes than the traditional spectral and complexity analyses. Our findings suggest that steeper aperiodic slopes may serve as a marker of network dysfunction in DLB and PD features.

Original languageEnglish
Pages (from-to)3958-3969
Number of pages12
JournalJournal of Neurology
Volume270
Issue number8
DOIs
StatePublished - Aug 2023

Keywords

  • 1/f power-law
  • Aperiodic activity
  • Dementia with Lewy bodies
  • Lempel–Ziv complexity
  • Neural oscillations
  • Parkinson’s disease

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