Decrease in LDL-C is associated with decrease in all components of noncalcified plaque on coronary CTA

Yuka Otaki; Balaji Tamarappoo; Sebastien J. Cadet; Mhairi Doris; Yoav Arnson; Phi T. Huynh; Heidi Gransar; Frances Wang; Sean W. Hayes; John D. Friedman; Louise Thomson; Piotr Slomka; Damini Dey; Daniel S. Berman

doi:10.1016/j.atherosclerosis.2019.04.201

Decrease in LDL-C is associated with decrease in all components of noncalcified plaque on coronary CTA

Yuka Otaki, Balaji Tamarappoo, Sebastien J. Cadet, Mhairi Doris, Yoav Arnson, Phi T. Huynh, Heidi Gransar, Frances Wang, Sean W. Hayes, John D. Friedman, Louise Thomson, Piotr Slomka, Damini Dey, Daniel S. Berman^*

^*Corresponding author for this work

Cedars-Sinai Medical Center

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background and aims: LDL-C reduction has been associated with a decrease in noncalcified plaque (NCP) by serial quantitative coronary CT angiography (CTA). We evaluated the effect of LDL-C reduction on specific components of noncalcified plaque (NCP). Methods: We analyzed 154 patients undergoing serial CTAs (118 men, 60 ± 10 years, interval 4 ± 2 years) with baseline LDL-C≥70 mg/dl. Semi-automated software was used for quantifying plaque components based on CT attenuation in Hounsfield units (HU): 30-75, low attenuation plaque (LAP); 76–130, medium-low attenuation plaque (MLAP); 131–350, medium attenuation plaque (MAP); >350, calcified plaque (CP). Decrease in LDL-C was defined as a reduction >10% of baseline LDL-C. Plaque volume changes were compared between patients with (n = 85) and without (n = 69) LDL-C decrease. Results: There was interval reduction in total plaque, LAP, MLAP, and MAP volumes in patients with LDL-C decrease vs. patients without LDL-C decrease before and after adjusting for differences between the two groups (all p ≤ 0.001). An increase in CP volume occurred in both groups (p = 0.42). Conclusions: Decrease in LDL-C was associated with reduction in all components of NCP measured by quantitative CTA. Change in total NCP volume may be the optimal measurement for assessing changes over time of coronary plaque on CTA.

Original language	English
Pages (from-to)	128-134
Number of pages	7
Journal	Atherosclerosis
Volume	285
DOIs	https://doi.org/10.1016/j.atherosclerosis.2019.04.201
State	Published - Jun 2019
Externally published	Yes

Funding

Funders	Funder number
Cardiac Imaging Research Initiative
National Heart, Lung, and Blood Institute	R56HL131871
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Keywords

Coronary CT angiography
Low-density lipoprotein cholesterol
Noncalcified plaque

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2019.04.201

Cite this

Otaki, Y., Tamarappoo, B., Cadet, S. J., Doris, M., Arnson, Y., Huynh, P. T., Gransar, H., Wang, F., Hayes, S. W., Friedman, J. D., Thomson, L., Slomka, P., Dey, D., & Berman, D. S. (2019). Decrease in LDL-C is associated with decrease in all components of noncalcified plaque on coronary CTA. Atherosclerosis, 285, 128-134. https://doi.org/10.1016/j.atherosclerosis.2019.04.201

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title = "Decrease in LDL-C is associated with decrease in all components of noncalcified plaque on coronary CTA",

abstract = "Background and aims: LDL-C reduction has been associated with a decrease in noncalcified plaque (NCP) by serial quantitative coronary CT angiography (CTA). We evaluated the effect of LDL-C reduction on specific components of noncalcified plaque (NCP). Methods: We analyzed 154 patients undergoing serial CTAs (118 men, 60 ± 10 years, interval 4 ± 2 years) with baseline LDL-C≥70 mg/dl. Semi-automated software was used for quantifying plaque components based on CT attenuation in Hounsfield units (HU): 30-75, low attenuation plaque (LAP); 76–130, medium-low attenuation plaque (MLAP); 131–350, medium attenuation plaque (MAP); >350, calcified plaque (CP). Decrease in LDL-C was defined as a reduction >10% of baseline LDL-C. Plaque volume changes were compared between patients with (n = 85) and without (n = 69) LDL-C decrease. Results: There was interval reduction in total plaque, LAP, MLAP, and MAP volumes in patients with LDL-C decrease vs. patients without LDL-C decrease before and after adjusting for differences between the two groups (all p ≤ 0.001). An increase in CP volume occurred in both groups (p = 0.42). Conclusions: Decrease in LDL-C was associated with reduction in all components of NCP measured by quantitative CTA. Change in total NCP volume may be the optimal measurement for assessing changes over time of coronary plaque on CTA.",

keywords = "Coronary CT angiography, Low-density lipoprotein cholesterol, Noncalcified plaque",

author = "Yuka Otaki and Balaji Tamarappoo and Cadet, {Sebastien J.} and Mhairi Doris and Yoav Arnson and Huynh, {Phi T.} and Heidi Gransar and Frances Wang and Hayes, {Sean W.} and Friedman, {John D.} and Louise Thomson and Piotr Slomka and Damini Dey and Berman, {Daniel S.}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = jun,

doi = "10.1016/j.atherosclerosis.2019.04.201",

language = "אנגלית",

volume = "285",

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T1 - Decrease in LDL-C is associated with decrease in all components of noncalcified plaque on coronary CTA

AU - Otaki, Yuka

AU - Tamarappoo, Balaji

AU - Cadet, Sebastien J.

AU - Doris, Mhairi

AU - Arnson, Yoav

AU - Huynh, Phi T.

AU - Gransar, Heidi

AU - Wang, Frances

AU - Hayes, Sean W.

AU - Friedman, John D.

AU - Thomson, Louise

AU - Slomka, Piotr

AU - Dey, Damini

AU - Berman, Daniel S.

PY - 2019/6

Y1 - 2019/6

N2 - Background and aims: LDL-C reduction has been associated with a decrease in noncalcified plaque (NCP) by serial quantitative coronary CT angiography (CTA). We evaluated the effect of LDL-C reduction on specific components of noncalcified plaque (NCP). Methods: We analyzed 154 patients undergoing serial CTAs (118 men, 60 ± 10 years, interval 4 ± 2 years) with baseline LDL-C≥70 mg/dl. Semi-automated software was used for quantifying plaque components based on CT attenuation in Hounsfield units (HU): 30-75, low attenuation plaque (LAP); 76–130, medium-low attenuation plaque (MLAP); 131–350, medium attenuation plaque (MAP); >350, calcified plaque (CP). Decrease in LDL-C was defined as a reduction >10% of baseline LDL-C. Plaque volume changes were compared between patients with (n = 85) and without (n = 69) LDL-C decrease. Results: There was interval reduction in total plaque, LAP, MLAP, and MAP volumes in patients with LDL-C decrease vs. patients without LDL-C decrease before and after adjusting for differences between the two groups (all p ≤ 0.001). An increase in CP volume occurred in both groups (p = 0.42). Conclusions: Decrease in LDL-C was associated with reduction in all components of NCP measured by quantitative CTA. Change in total NCP volume may be the optimal measurement for assessing changes over time of coronary plaque on CTA.

AB - Background and aims: LDL-C reduction has been associated with a decrease in noncalcified plaque (NCP) by serial quantitative coronary CT angiography (CTA). We evaluated the effect of LDL-C reduction on specific components of noncalcified plaque (NCP). Methods: We analyzed 154 patients undergoing serial CTAs (118 men, 60 ± 10 years, interval 4 ± 2 years) with baseline LDL-C≥70 mg/dl. Semi-automated software was used for quantifying plaque components based on CT attenuation in Hounsfield units (HU): 30-75, low attenuation plaque (LAP); 76–130, medium-low attenuation plaque (MLAP); 131–350, medium attenuation plaque (MAP); >350, calcified plaque (CP). Decrease in LDL-C was defined as a reduction >10% of baseline LDL-C. Plaque volume changes were compared between patients with (n = 85) and without (n = 69) LDL-C decrease. Results: There was interval reduction in total plaque, LAP, MLAP, and MAP volumes in patients with LDL-C decrease vs. patients without LDL-C decrease before and after adjusting for differences between the two groups (all p ≤ 0.001). An increase in CP volume occurred in both groups (p = 0.42). Conclusions: Decrease in LDL-C was associated with reduction in all components of NCP measured by quantitative CTA. Change in total NCP volume may be the optimal measurement for assessing changes over time of coronary plaque on CTA.

KW - Coronary CT angiography

KW - Low-density lipoprotein cholesterol

KW - Noncalcified plaque

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SN - 0021-9150

VL - 285

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EP - 134

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Decrease in LDL-C is associated with decrease in all components of noncalcified plaque on coronary CTA

Abstract

Funding

Keywords

UN SDGs

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