Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur

C. Lidor; P. Sagiv; B. Amdur; R. Gepstein; I. Otremski; T. Hallel; S. Edelstein

doi:10.1007/BF00308324

Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur

C. Lidor, P. Sagiv, B. Amdur, R. Gepstein, I. Otremski, T. Hallel, S. Edelstein

Research output: Contribution to journal › Article › peer-review

Abstract

In a previous study we were able to show that in women over the age of 45 the level of 1,25-dihydroxyvitamin D (1,25(OH)₂D) in bone, but not in serum, is significantly reduced when compared with younger women. In the present study we measured the concentration of 1,25(OH)₂D in sera and bones of 19 female patients with subcapital fractures of the femur, mean age 78±2 years. We were able to show that serum levels of 1,25(OH)₂D were within the normal range, while bone levels were markedly reduced compared to levels in femoral bone obtained from young female cadavers or to the previously reported levels in non-osteoporotic elderly women. Thus, reduced levels of 1,25(OH)₂D in bones of elderly women may lead, together with other factors, to subcapital fractures.

Original language	English
Pages (from-to)	146-148
Number of pages	3
Journal	Calcified Tissue International
Volume	52
Issue number	2
DOIs	https://doi.org/10.1007/BF00308324
State	Published - Feb 1993

Keywords

Calcitriol
Femoral Fracture
Osteoporosis
Vitamin D

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00308324

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title = "Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur",

abstract = "In a previous study we were able to show that in women over the age of 45 the level of 1,25-dihydroxyvitamin D (1,25(OH)2D) in bone, but not in serum, is significantly reduced when compared with younger women. In the present study we measured the concentration of 1,25(OH)2D in sera and bones of 19 female patients with subcapital fractures of the femur, mean age 78±2 years. We were able to show that serum levels of 1,25(OH)2D were within the normal range, while bone levels were markedly reduced compared to levels in femoral bone obtained from young female cadavers or to the previously reported levels in non-osteoporotic elderly women. Thus, reduced levels of 1,25(OH)2D in bones of elderly women may lead, together with other factors, to subcapital fractures.",

keywords = "Calcitriol, Femoral Fracture, Osteoporosis, Vitamin D",

author = "C. Lidor and P. Sagiv and B. Amdur and R. Gepstein and I. Otremski and T. Hallel and S. Edelstein",

year = "1993",

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AU - Lidor, C.

AU - Sagiv, P.

AU - Amdur, B.

AU - Gepstein, R.

AU - Otremski, I.

AU - Hallel, T.

AU - Edelstein, S.

PY - 1993/2

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N2 - In a previous study we were able to show that in women over the age of 45 the level of 1,25-dihydroxyvitamin D (1,25(OH)2D) in bone, but not in serum, is significantly reduced when compared with younger women. In the present study we measured the concentration of 1,25(OH)2D in sera and bones of 19 female patients with subcapital fractures of the femur, mean age 78±2 years. We were able to show that serum levels of 1,25(OH)2D were within the normal range, while bone levels were markedly reduced compared to levels in femoral bone obtained from young female cadavers or to the previously reported levels in non-osteoporotic elderly women. Thus, reduced levels of 1,25(OH)2D in bones of elderly women may lead, together with other factors, to subcapital fractures.

AB - In a previous study we were able to show that in women over the age of 45 the level of 1,25-dihydroxyvitamin D (1,25(OH)2D) in bone, but not in serum, is significantly reduced when compared with younger women. In the present study we measured the concentration of 1,25(OH)2D in sera and bones of 19 female patients with subcapital fractures of the femur, mean age 78±2 years. We were able to show that serum levels of 1,25(OH)2D were within the normal range, while bone levels were markedly reduced compared to levels in femoral bone obtained from young female cadavers or to the previously reported levels in non-osteoporotic elderly women. Thus, reduced levels of 1,25(OH)2D in bones of elderly women may lead, together with other factors, to subcapital fractures.

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KW - Femoral Fracture

KW - Osteoporosis

KW - Vitamin D

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Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur

Abstract

Keywords

UN SDGs

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