TY - JOUR
T1 - Decoding of dopaminergic mesolimbic activity and depressive behavior
AU - Friedman, Alexander
AU - Deri, Ilana
AU - Friedman, Yaakov
AU - Dremencov, Eliyahu
AU - Goutkin, Sophia
AU - Kravchinsky, Elizabeth
AU - Mintz, Matti
AU - Levi, Dino
AU - Overstreet, David H.
AU - Yadid, Gal
N1 - Funding Information:
Acknowledgements This study was supported in part by a grant from The Israel Science Foundation to GY. We wish to thank Professors Moshe Abeles and Uziel Sandier for critically reviewing the manuscript and Dr. Barbara Schick for her comments.
PY - 2007/5
Y1 - 2007/5
N2 - Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Previously, we showed decreased limbic dopamine (DA) neurotransmission in an animal model of depression, Flinder sensitive line (FSL) rats. Here we describe a high correlation between phase-space algorithm of bursting-like activity of DA cells in the ventral tegmental area (VTA) and efficiency of DA release in the accumbens. This bursting-like activity of VTA DA cells of FSL rats is characterized by a low dimension complexity. Treatment with the antidepressant desipramine affected both the dimension complexity of cell firing in the VTA and rate of DA release in the accumbens, as well as alleviating depressive-like behavior. Our findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with non-linear analysis. Decoding the functionality of the dopaminergic system may help in development of future antidepressant drugs.
AB - Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Previously, we showed decreased limbic dopamine (DA) neurotransmission in an animal model of depression, Flinder sensitive line (FSL) rats. Here we describe a high correlation between phase-space algorithm of bursting-like activity of DA cells in the ventral tegmental area (VTA) and efficiency of DA release in the accumbens. This bursting-like activity of VTA DA cells of FSL rats is characterized by a low dimension complexity. Treatment with the antidepressant desipramine affected both the dimension complexity of cell firing in the VTA and rate of DA release in the accumbens, as well as alleviating depressive-like behavior. Our findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with non-linear analysis. Decoding the functionality of the dopaminergic system may help in development of future antidepressant drugs.
KW - Dimension analysis
KW - Dopamine
KW - Electrophysiology
KW - Flinders Sensitive Line of rats
KW - Motivation
KW - Nonlinear analysis
KW - Swim test
KW - Ventral tegmental area
UR - http://www.scopus.com/inward/record.url?scp=34548844506&partnerID=8YFLogxK
U2 - 10.1007/s12031-007-0016-5
DO - 10.1007/s12031-007-0016-5
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AN - SCOPUS:34548844506
VL - 32
SP - 72
EP - 79
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
SN - 0895-8696
IS - 1
ER -