Decision-making dysregulation in first-episode schizophrenia

Katja Cattapan-Ludewig*, Stephan Ludewig, Nadine Messerli, Franz X. Vollenweider, Antonia Seitz, Joram Feldon, Martin P. Paulus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalJournal of Nervous and Mental Disease
Issue number2
StatePublished - Feb 2008
Externally publishedYes


  • Decision making
  • Dysregulation
  • Entropy
  • Schizophrenia
  • Two-choice prediction task


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